Insights into the mechanisms of triptolide nephrotoxicity through network pharmacology-based analysis and RNA-seq

Triptolide (TPL) is a promising plant-derived compound for clinical therapy of multiple human diseases; however, its application was limited considering its toxicity. To explore the underlying molecular mechanism of TPL nephrotoxicity, a network pharmacology based approach was utilized to predict ca...

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Published inFrontiers in plant science Vol. 14; p. 1144583
Main Authors Luo, Yue-Ming, Yang, Shu-Dong, Wen, Miao-Yu, Wang, Bing, Liu, Jia-Hui, Li, Si-Ting, Li, Yu-Yan, Cheng, Hong, Zhao, Li-Li, Li, Shun-Min, Jiang, Jian-Jun
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 07.03.2023
Subjects
nephrotoxicity
network pharmacology
noncoding RNA
Plant Science
RNA-seq
triptolide
triptolide
noncoding RNA
RNA-seq
nephrotoxicity
network pharmacology
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Summary:Triptolide (TPL) is a promising plant-derived compound for clinical therapy of multiple human diseases; however, its application was limited considering its toxicity. To explore the underlying molecular mechanism of TPL nephrotoxicity, a network pharmacology based approach was utilized to predict candidate targets related with TPL toxicity, followed by deep RNA-seq analysis to characterize the features of three transcriptional elements include protein coding genes (PCGs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) as well as their associations with nephrotoxicity in rats with TPL treatment. Although the deeper mechanisms of TPL nephrotoxcity remain further exploration, our results suggested that c-Jun is a potential target of TPL and Per1 related circadian rhythm signaling is involved in TPL induced renal toxicity.
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Reviewed by: Xiaojie Wang, Shandong University, China; Peihao Fan, University of Pittsburgh, United States
This article was submitted to Plant Bioinformatics, a section of the journal Frontiers in Plant Science
These authors have contributed equally to this work and share first authorship
Edited by: Penghui Li, Anhui Agricultural University, China
ISSN:1664-462X
1664-462X
DOI:10.3389/fpls.2023.1144583