Electrochemical paper-based devices: sensing approaches and progress toward practical applications
Paper-based sensors offer an affordable yet powerful platform for field and point-of-care (POC) testing due to their self-pumping ability and utility for many different analytical measurements. When combined with electrochemical detection using small and portable electronics, sensitivity and selecti...
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| Published in | Lab on a chip Vol. 2; no. 1; pp. 9 - 34 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
07.01.2020
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Paper-based sensors offer an affordable yet powerful platform for field and point-of-care (POC) testing due to their self-pumping ability and utility for many different analytical measurements. When combined with electrochemical detection using small and portable electronics, sensitivity and selectivity of the paper devices can be improved over naked eye detection without sacrificing portability. Herein, we review how the field of electrochemical paper-based analytical devices (ePADs) has grown since it was introduced a decade ago. We start by reviewing fabrication methods relevant to ePADs with more focus given to the electrode fabrication, which is fundamental for electrochemical sensing. Multiple sensing approaches applicable to ePADs are then discussed and evaluated to present applicability, advantages and challenges associated with each approach. Recent applications of ePADs in the fields of clinical diagnostics, environmental testing, and food analysis are also presented. Finally, we discuss how the current ePAD technologies have progressed to meet the analytical and practical specifications required for field and/or POC applications, as well as challenges and outlook.
Paper-based sensors offer an affordable yet powerful platform for field and point-of-care (POC) testing due to their self-pumping ability and utility for many different analytical measurements. |
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| Bibliography: | Charles S. Henry received his Ph.D. from the University of Arkansas followed by postdoctoral studies at the University of Kansas. He started his academic career at Mississippi State University before moving to Colorado State University in 2002, where he is currently Professor of Chemistry. His research interests lie broadly in the areas of microfluidics and electrochemistry with application to questions in bioanalytical and environmental chemistry. Cynthia P. McCord received her B.S. in Chemistry from the University of West Florida in 2016. She is currently a 4th year analytical chemistry graduate student at Colorado State University. Her research focus is using thermoplastic carbon composite electrodes for electrochemical biosensing. Kaylee M. Clark received her B.S. in Chemistry from Clemson University in 2017. Currently, she is a graduate student in the Chemistry Department at Colorado State University. Her current research is using thermoplastic electrodes to develop low-cost electrochemical devices for bioanalytical applications. Ilhoon Jang received his Ph.D. in Mechanical Engineering from Hanyang University in 2018. He is currently a postdoctoral fellow in the Institute of Nano Science and Technology at Hanyang University, and a visiting researcher in the Chemistry Department at Colorado State University. His research focuses on flow control and modeling in paper-based analytical devices. Eka Noviana obtained her B.S. in Pharmaceutical Science from Universitas Gadjah Mada, Indonesia, in 2012. She received her M.S. in Chemistry from the University of Arizona in 2015. She is currently a Ph.D. candidate at Colorado State University. Her research focuses on developing low-cost colorimetric and electrochemical sensors for bioanalytical applications. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ISSN: | 1473-0197 1473-0189 1473-0189 |
| DOI: | 10.1039/c9lc00903e |