American college of radiology ovarian-adnexal reporting and data system ultrasound (O-RADS): Diagnostic performance and inter-reviewer agreement for ovarian masses in children

To evaluate the diagnostic performance and inter-observer agreement of the American College of Radiology Ovarian-Adnexal Reporting and Data System Ultrasound (O-RADS) in the diagnosis of ovarian masses in children. From June 2012 to December 2021, 163 ovarian masses in 159 patients with pathologic r...

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Published inFrontiers in pediatrics Vol. 11; p. 1091735
Main Authors Wang, Huimin, Wang, Limin, An, Siwei, Ma, Qiuping, Tu, Yanping, Shang, Ning, Pan, Yunxiang
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 08.03.2023
Subjects
children
diagnostic performance
O-RADS
ovarian masses
Pediatrics
ultrasound
diagnostic performance
O-RADS
children
ovarian masses
ultrasound
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Summary:To evaluate the diagnostic performance and inter-observer agreement of the American College of Radiology Ovarian-Adnexal Reporting and Data System Ultrasound (O-RADS) in the diagnosis of ovarian masses in children. From June 2012 to December 2021, 163 ovarian masses in 159 patients with pathologic results were retrospectively analyzed. Each mass was classified into an O-RADS category according to the criteria. The diagnostic performance of O-RADS for detecting malignant ovarian masses was assessed using histopathology as the reference standard. Kappa ( ) statistic was used to assess inter-observer agreement between a less-experienced and a well-experienced radiologist. Out of 163 ovarian masses, 18 (11.0%) were malignant and 145 (89.0%) were benign. The malignancy rates of O-RADS 5, O-RADS 4, and O-RADS 3 masses were 72.7%, 34.6%, and 4.8%, respectively. The area under the receiver operating characteristic curve was 0.944 (95% CI, 0.908-0.981). The optimal cutoff value for predicting malignant ovarian masses was  > O-RADS 3 with a sensitivity, specificity, and accuracy of 94.4%, 86.2% and 86.2% respectively. The inter-observer agreement of the O-RADS category was good ( = 0.777). O-RADS has a high diagnostic performance for children with ovarian masses. It provides an effective malignant risk classification for ovarian masses in children, which shows high consistency between radiologists with different levels of experience.
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Abbreviations O-RADS, Ovarian-Adnexal Reporting and Data System Ultrasound; k, kappa; PACS, Picture Archiving and Communication System; ROC, Receiver operating characteristic; AUC, area under the curve.
Edited by: Joanna Kitlinska, Georgetown University, United States
These authors have contributed equally to this work and share first authorship
Specialty Section: This article was submitted to Pediatric Oncology, a section of the journal Frontiers in Pediatrics
Reviewed by: Jacques Abramowicz, The University of Chicago, United States Ekaterini Domali, National and Kapodistrian University of Athens, Greece
ISSN:2296-2360
2296-2360
DOI:10.3389/fped.2023.1091735