Relative utility of 1-h Oral Glucose Tolerance Test as a measure of abnormal glucose homeostasis

• Published in: Diabetes research and clinical practice Vol. 93; no. 2; pp. 268 - 275
• Main Authors: Joshipura, K.J, Andriankaja, M.O, Hu, F.B, Ritchie, C.S
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.08.2011
• Subjects: 1-h OGTT; 2-h OGTT; Abnormal glucose homeostasis; Adiposity; Adult; Aged; Blood Glucose - analysis; Blood Glucose - metabolism; Body Mass Index; Endocrinology & Metabolism; Female; Glucose abnormalities; Glucose Tolerance Test - methods; Glucose Tolerance Test - standards; Homeostasis; Humans; Insulin - blood; Male; Metabolic Syndrome - diagnosis; Middle Aged; Time Factors; Type 2 diabetes; Waist Circumference; Type 2 diabetes; Glycosylated hemoglobin; Cardiovascular disease; High density lipoprotein; IFG; HDL; Body mass index; Fasting plasma glucose; Abnormal glucose homeostasis; LDL; 2-h OGTT; Adult treatment panel; HbA1c; Impaired glucose tolerance; 1-h OGTT; BMI; Oral Glucose Tolerance Test; Impaired fasting glucose; Glucose abnormalities; Hour; h; IR; Low density lipoprotein; CVD; IGT; Insulin resistance; OGTT; FPG; ATP
• ISSN: 0168-8227; 1872-8227
• DOI: 10.1016/j.diabres.2011.05.035

Abstract Background and aims Impaired glucose tolerance based on 2-h glucose levels is more predictive of future cardiovascular disease and more sensitive in detecting earlier diabetes compared to impaired fasting glucose. However, the 1-h OGTT may be even more sensitive than the 2-h. We assessed the relative value of 1-h OGTT by exploring its relationship with adiposity and other measures of glucose homeostasis. Methods and results Ninety four overweight/obese individuals free of diabetes and major cardiovascular conditions were included in the analyses. We adjusted for age, gender, smoking status and physical activity. One-h OGTT showed similar partial correlations with fasting glucose and 2-h OGTT ( r = 0.60 and 0.64 respectively). Fasting glucose, fasting insulin and HOMA correlated better with 1-h OGTT ( r = 0.60, 0.47 and 0.52) than with 2-h OGTT ( r = 0.50, 0.41, and 0.45). BMI and waist circumference also showed stronger correlation with 1-h ( r = 0.31, 0.29), compared to 2-h OGTT ( r = 0.16, 0.16) or fasting glucose ( r = 0.23, 0.22). Metabolic syndrome was associated similarly with 1-h and 2-h OGTT. Conclusions The 1-h OGTT correlates well with both fasting glucose and 2-h OGTT and shows similar or higher associations with obesity measures. The 1-h OGTT has potential utility in epidemiologic studies.