Relative utility of 1-h Oral Glucose Tolerance Test as a measure of abnormal glucose homeostasis
Abstract Background and aims Impaired glucose tolerance based on 2-h glucose levels is more predictive of future cardiovascular disease and more sensitive in detecting earlier diabetes compared to impaired fasting glucose. However, the 1-h OGTT may be even more sensitive than the 2-h. We assessed th...
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Published in | Diabetes research and clinical practice Vol. 93; no. 2; pp. 268 - 275 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Ireland
Elsevier B.V
01.08.2011
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Subjects | |
Online Access | Get full text |
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Summary: | Abstract Background and aims Impaired glucose tolerance based on 2-h glucose levels is more predictive of future cardiovascular disease and more sensitive in detecting earlier diabetes compared to impaired fasting glucose. However, the 1-h OGTT may be even more sensitive than the 2-h. We assessed the relative value of 1-h OGTT by exploring its relationship with adiposity and other measures of glucose homeostasis. Methods and results Ninety four overweight/obese individuals free of diabetes and major cardiovascular conditions were included in the analyses. We adjusted for age, gender, smoking status and physical activity. One-h OGTT showed similar partial correlations with fasting glucose and 2-h OGTT ( r = 0.60 and 0.64 respectively). Fasting glucose, fasting insulin and HOMA correlated better with 1-h OGTT ( r = 0.60, 0.47 and 0.52) than with 2-h OGTT ( r = 0.50, 0.41, and 0.45). BMI and waist circumference also showed stronger correlation with 1-h ( r = 0.31, 0.29), compared to 2-h OGTT ( r = 0.16, 0.16) or fasting glucose ( r = 0.23, 0.22). Metabolic syndrome was associated similarly with 1-h and 2-h OGTT. Conclusions The 1-h OGTT correlates well with both fasting glucose and 2-h OGTT and shows similar or higher associations with obesity measures. The 1-h OGTT has potential utility in epidemiologic studies. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0168-8227 1872-8227 |
DOI: | 10.1016/j.diabres.2011.05.035 |