Continuous glucose monitoring in cystic fibrosis – A practical guide

• Published in: Journal of cystic fibrosis Vol. 18; pp. S25 - S31
• Main Authors: Chan, Christine L., Ode, Katie Larson, Granados, Andrea, Moheet, Amir, Moran, Antoinette, Hameed, Shihab
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2019
• Subjects: Artificial pancreas; Blood Glucose - analysis; Blood Glucose Self-Monitoring - instrumentation; Continuous glucose monitoring; Cystic Fibrosis - blood; Cystic Fibrosis - complications; Cystic fibrosis related diabetes; Diabetes Mellitus - blood; Diabetes Mellitus - diagnosis; Diabetes Mellitus - etiology; Equipment Design; Humans; Continuous glucose monitoring; Artificial pancreas; CGM; SMBG; CFRD; OGTT; HbA1c; Cystic fibrosis related diabetes
• ISSN: 1569-1993; 1873-5010
• DOI: 10.1016/j.jcf.2019.08.025

Our ability to monitor blood glucose levels has become increasingly accurate over the last few decades. Continuous glucose monitoring (CGM) technology now allows providers and patients the ability to monitor glucose levels retrospectively as well as in real-time for diabetes management. CGM also provides the ability to study glucose patterns and trends for insight into the pathophysiology and natural history of disease. CGM captures a more complete picture of glucose profiles than traditional measures of glycemia such as the hemoglobin A1c or self-monitoring of blood glucose levels. This article provides a review of the history of glucose monitoring, a review of the literature pertaining to CGM with a focus on studies in patients with cystic fibrosis, and discusses practical uses of CGM technology and its application for the evaluation and management of cystic fibrosis related diabetes. •CGM systems are useful adjunctive tools for the screening and monitoring of CFRD.•CGM abnormalities may be present even in individuals with normal glucose tolerance.•Abnormalities on CGM correlate with adverse outcomes including reduced FEV1 and BMI.•No official CGM guidelines have been published to guide CFRD management.