Absence of association between polymorphisms in the K13 gene and the presence of Plasmodium falciparum parasites at day 3 after treatment with artemisinin derivatives in Senegal

• Published in: International journal of antimicrobial agents Vol. 49; no. 6; pp. 754 - 756
• Main Authors: Madamet, Marylin, Kounta, Mame Bou, Wade, Khalifa Ababacar, Lo, Gora, Diawara, Silman, Fall, Mansour, Bercion, Raymond, Nakoulima, Aminata, Fall, Khadidiatou Ba, Benoit, Nicolas, Gueye, Mamadou Wague, Fall, Bécaye, Diatta, Bakary, Pradines, Bruno
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2017; Elsevier
• Subjects: Animals; Antimalarial drug; Antimalarials - therapeutic use; Artemisinin resistance; Artemisinins - therapeutic use; Human health and pathology; Humans; Infectious Disease; Infectious diseases; K13-propeller; Life Sciences; Malaria; Malaria, Falciparum - drug therapy; Malaria, Falciparum - parasitology; Molecular marker; Mutation, Missense; Plasmodium falciparum; Plasmodium falciparum - drug effects; Plasmodium falciparum - genetics; Plasmodium falciparum - isolation & purification; Point Mutation; Polymorphism, Genetic; Protozoan Proteins - genetics; Senegal; Sequence Analysis, DNA; Time Factors; Treatment Outcome; K13-propeller; Plasmodium falciparum; Artemisinin resistance; Antimalarial drug; Molecular marker; Malaria
• ISSN: 0924-8579; 1872-7913
• DOI: 10.1016/j.ijantimicag.2017.01.032

Highlights • The K13-propeller gene of 181 isolates from Senegalese patients collected in 2015–2016 was sequenced. • Nine of 119 patients treated with artesunate or artemether followed by artemether/lumefantrine were parasitaemic on Day 3. • Three synonymous mutations were detected in K13 (D464D, C469C and R471R); no non-synonymous mutations were detected. • None of the polymorphisms known to be involved in artemisinin resistance in Asia were detected. • K13 is not the best predictive marker for artemisinin resistance in Africa.