Effect of brain tumor neovasculature defined by rCBV on BOLD fMRI activation volume in the primary motor cortex

• Published in: NeuroImage (Orlando, Fla.) Vol. 32; no. 2; pp. 489 - 497
• Main Authors: Hou, Bob L., Bradbury, Michelle, Peck, Kyung K., Petrovich, Nicole M., Gutin, Philip H., Holodny, Andrei I.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.08.2006; Elsevier Limited
• Subjects: Adult; Aged; Aged, 80 and over; Astrocytoma - blood supply; Blood Oxygenation Level Dependent; Blood Volume - physiology; Brain; Brain cancer; Brain Neoplasms - physiopathology; Brain Neoplasms - secondary; Female; Functional Magnetic Resonance Imaging; Glioblastoma - blood supply; Glioblastoma Multiforme; Hemangiopericytoma - blood supply; Humans; Image Enhancement; Image Processing, Computer-Assisted; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Meningeal Neoplasms - blood supply; Meningioma - blood supply; Middle Aged; Motor Cortex - blood supply; Neovascularization, Pathologic - physiopathology; Neurons - physiology; NMR; Nuclear magnetic resonance; Oligodendroglioma - blood supply; Oxygen - blood; Patients; Prime Motor Cortex; Regional Blood Flow - physiology; Relative Regional Cerebral Blood Volume; Statistics as Topic; Surgery; Tumors; Prime Motor Cortex; Blood Oxygenation Level Dependent; Glioblastoma Multiforme; Relative Regional Cerebral Blood Volume; Functional Magnetic Resonance Imaging
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2006.04.188

We utilized blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) and MR perfusion imaging methods to study the influence of brain tumor neovascularity on the BOLD fMRI activation volume in the primary motor cortex (PMC). The results from 57 brain tumor cases demonstrated that, for grade IV gliomas only, decreases in the BOLD fMRI activation volumes within the ipsilateral PMC, when compared with that observed in the contralateral PMC, correlated with increases in the relative regional cerebral blood volume (rCBV) in the PMC. In addition, relative increases in the activation volumes, corresponding to decreases in the rCBV, exhibited a linear dependence on the distance between the grade IV glioma and PMC. These findings lend support to the hypothesis that decreases in the fMRI activation volumes adjacent to a GBM may, in part, be due to the increased contribution of aberrant tumor neovascularity, with the resultant de-coupling of blood flow from neuronal activity. The nature of the relationship between the resulting activation volumes and adjacent tumor characteristics is complex, but is found to be dependent on the tumor grade and type, as well as the distance of the tumor to the PMC.