Results of the Brazilian Osteosarcoma Treatment Group Studies III and IV: Prognostic Factors and Impact on Survival

• Published in: Journal of clinical oncology Vol. 24; no. 7; pp. 1161 - 1168
• Main Authors: SERGIO PETRILLI, A, DE CAMARGO, Beatriz, PROSPERO, José D, ALVES, Maria Teresa S, OLIVEIRA, Claudia R, MACEDO, Carla R. D, MENDES, Wellington L, ALMEIDA, Maria Teresa A, BORSATO, Maria L, DOS SANTOS, Telma M, ORTEGA, Jorge, CONSENTINO, Elio, ODONE FILHO, Vicente, BRUNIERA, Paula, BRUNETTO, Algemir L, JESUS-GARCIA, Reynaldo, CAMARGO, Olavo P, PENA, Walter, PERICLES, Pedro, DAVI, Alexandre
• Format: Journal Article
• Language: English
• Published: Baltimore, MD American Society of Clinical Oncology 01.03.2006; Lippincott Williams & Wilkins
• Subjects: Adolescent; Amputation; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Bone Neoplasms - drug therapy; Bone Neoplasms - pathology; Bone Neoplasms - surgery; Brazil; Carboplatin - administration & dosage; Chemotherapy, Adjuvant; Child; Cisplatin - administration & dosage; Disease-Free Survival; Diseases of the osteoarticular system; Doxorubicin - administration & dosage; Epirubicin - administration & dosage; Female; Humans; Ifosfamide - administration & dosage; Limb Salvage; Lung Neoplasms - drug therapy; Lung Neoplasms - secondary; Lung Neoplasms - surgery; Male; Medical sciences; Methotrexate - administration & dosage; Multivariate Analysis; Orthopedic Procedures - methods; Osteosarcoma - drug therapy; Osteosarcoma - secondary; Osteosarcoma - surgery; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Prospective Studies; Risk Factors; Survival Analysis; Treatment Outcome; Tumors; Tumors of striated muscle and skeleton; South America; Brazil; America; Osteoarticular system; Cancerology; Prognosis; Treatment; Sarcoma; Osteosarcoma; Diseases of the osteoarticular system; Malignant tumor; Bone; Survival
• ISSN: 0732-183X; 1527-7755
• DOI: 10.1200/JCO.2005.03.5352

To evaluate the impact of chemotherapy and surgery on the outcome of osteosarcoma (OS) of the extremities and to identify prognostic factors in Brazilian patients. A total of 225 patients with metastatic and nonmetastatic OS of the extremities were enrolled and assessed in two consecutive studies designed and implemented by the Brazilian Osteosarcoma Treatment Group. The 5-year survival and event-free survival rates for the 209 assessable patients were 50.1% and 39%, respectively; for the 178 patients with nonmetastatic disease at diagnosis, the rates were 60.5% and 45.5%, respectively. The multivariate analysis showed that the following variables were associated with a shorter survival: metastases at diagnosis (P < .001), necrosis grades 1 and 2 (P = .046), and tumor size (P = .0071). The overall 5- and 10-year survival rates were lower than the rates reported in North American and European trials. A pattern of advanced disease at diagnosis was often present, with a high proportion of patients having metastases (20.8%) and large tumor size (42.9%). However, these features were not necessarily associated with longer duration of prediagnostic symptoms. These findings were considered in the strategic planning of the current Brazilian cooperative study, with the aim of improving survival and quality of life of a large number of patients with OS.