A Tumor-Associated Fibronectin Isoform Generated by Alternative Splicing of Messenger RNA Precursors

• Published in: The Journal of cell biology Vol. 108; no. 3; pp. 1139 - 1148
• Main Authors: Carnemolla, Barbara, Balza, Enrica, Siri, Annalisa, Zardi, Luciano, Nicotra, Maria Rita, Bigotti, Aldo, Natali, Pier Giorgio
• Format: Journal Article
• Language: English
• Published: New York, NY Rockefeller University Press 01.03.1989; The Rockefeller University Press
• Subjects: Alternative splicing; Analytical, structural and metabolic biochemistry; Antibodies, Monoclonal; Biological and medical sciences; Biotechnology; Cell Line; Cell lines; Cells; Epitopes; Exons; Female; Fetus; Fetus - analysis; Fibroblasts; Fibronectins - analysis; Fibronectins - genetics; Fibronectins - immunology; Fundamental and applied biological sciences. Psychology; Glycoproteins; Health. Pharmaceutical industry; Humans; Immunoenzyme Techniques; Industrial applications and implications. Economical aspects; Messenger RNA; Miscellaneous; Monoclonal antibodies; Myometrium - analysis; Neoplasms - analysis; Ovary - analysis; Production of active biomolecules; Protein isoforms; Proteins; RNA Precursors - genetics; RNA Splicing; Synovial Membrane - analysis; Tumor cell line; Tumors; Characterization; Human; Immunohistochemistry; Tissue; Production; Glycoproteins; Monoclonal antibody; Gene expression; Localization; Fibronectin; Aminoacid sequence; Isomer

Fibronectin (FN) represents the mixture of a number of structurally different molecules (isoforms) whose make-up varies depending on the FN sources. FN from cultured transformed human cells has a very different isoform composition with respect to its normal counterpart. In fact, SV-40-transformed WI...