Effect of ovariectomy on bone remodeling adjacent to hydroxyapatite-coated implants in the tibia of mature rats

• Published in: Journal of oral and maxillofacial surgery Vol. 58; no. 8; pp. 877 - 882
• Main Authors: Pan, Juli, Shirota, Tatsuo, Ohno, Kohsuke, Michi, Ken-ichi
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.08.2000; Elsevier
• Subjects: Animals; Biological and medical sciences; Bone Density; Bone Remodeling; Coated Materials, Biocompatible; Dental Implantation, Endosseous; Dentistry; Disease Models, Animal; Durapatite; Estrogens - deficiency; Female; Humans; Medical sciences; Orthopedic surgery; Osseointegration; Osteoporosis, Postmenopausal - physiopathology; Ovariectomy; Ovary - physiology; Prostheses and Implants; Rats; Rats, Wistar; Statistics, Nonparametric; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the genital tract and mammary gland; Tibia - pathology; Implant; Ovariectomy; Rat; Deficiency; Rodentia; Estrogen; Hydroxyapatite; Bone remodeling; Experimental study; Vertebrata; Mammalia; Treatment; Tibia; Surgery; Animal; Biological effect
• ISSN: 0278-2391; 1531-5053
• DOI: 10.1053/joms.2000.8212

Purpose: The purpose of this study was to examine the effects of estrogen deficiency on bone remodeling adjacent to implants in the tibia of mature rats. Materials and Methods: Hydroxyapatite-coated implants were placed bilaterally in the proximal metaphysis of the tibia of 18 female Wistar rats (48 weeks old), and ovariectomy was performed 168 days later. As a control, sham ovariectomy was performed in a similar group of 18 rats. Six animals from each group were killed at 28, 84, and 168 days after ovariectomy. Undecalcified sections were prepared, and changes in the bone tissue around the implants were evaluated histologically. Histomorphometric measurements were made with a computer-based image analyzer to quantify the unit bone mass around each implant and the amount of implant-bone contact. Results: In the cortical bone area, ovariectomy induced only a slight decrease in bone contact with the implant, compared with that in the sham-operated rats. However, both the bone volume around the implant and implant-bone contact were significantly decreased in the cancellous bone area in ovariectomized rats compared with the sham-operated rats. Conclusion: Thinning of the bone trabeculae holding dental implants may occur with estrogen deficiency. © 2000 American Association of Oral and Maxillofacial Surgeons