The use of hyperbaric oxygen therapy in the treatment of hemorrhagic cystitis after allogeneic stem cell transplantation from an unrelated donor

Hemorrhagic cystitis (HC) is a diffuse inflammation of the bladder of an infectious or non-infectious etiology, causing bleeding of the bladder mucosa. There are no explicit guidelines defining the appropriate treatment of HC. Hyperbaric oxygen therapy (HBO) is a non-invasive method involving the us...

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Published inInternational journal of hematology Vol. 102; no. 3; pp. 364 - 367
Main Authors Urbaniak-Kujda, Donata, Kapelko-Słowik, Katarzyna, Biernat, Monika, Dybko, Jarosław, Laszkowska, Magdalena, Kuliczkowski, Kazimierz
Format Journal Article
LanguageEnglish
Published Tokyo Springer Japan 01.09.2015
Springer Nature B.V
Subjects
Adult
Allografts
Cystitis - etiology
Cystitis - therapy
Female
Hematology
Hematopoietic Stem Cell Transplantation
Hemorrhage - etiology
Hemorrhage - therapy
Humans
Hyperbaric Oxygenation
Male
Medicine
Medicine & Public Health
Oncology
Original Article
Time Factors
Unrelated Donors
Hyperbaric oxygen therapy
Allogeneic stem cell transplantation
Hemorrhagic cystitis
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Summary:Hemorrhagic cystitis (HC) is a diffuse inflammation of the bladder of an infectious or non-infectious etiology, causing bleeding of the bladder mucosa. There are no explicit guidelines defining the appropriate treatment of HC. Hyperbaric oxygen therapy (HBO) is a non-invasive method involving the use of 100 % oxygen under increased pressure, which penetrates to poorly perfused areas. The most appropriate group for treatment with HBO is patients with BK virus-associated HC after allogenic human stem cell transplantation (alloHSCT). In this report, we present five patients after alloHSCT from a matched unrelated donor with symptoms of HC successfully treated with HBO. All patients received therapy with 100 % oxygen in a hyperbaric chamber at 2.5 atmospheres for 60 min, delivered 5 days per week. Complete response with resolution of pain and hematuria, as well as eradication of viral load, was achieved by all the patients after a mean of 13 sessions (range 11–30) of HBO. These data indicate that HBO therapy is sufficient and effective in the treatment of HC, and represents a well-tolerated procedure with good clinical and laboratory results after ineffective primary treatment.
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ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-015-1832-y