The Development of AIDS-Associated Burkitt's/Small Noncleaved Cell Lymphoma Is Preceded by Elevated Serum Levels of Interleukin 6

• Published in: Clinical immunology (Orlando, Fla.) Vol. 92; no. 3; pp. 293 - 299
• Main Authors: Crabb Breen, Elizabeth, van der Meijden, Meta, Cumberland, William, Kishimoto, Tadamitsu, Detels, Roger, Martı́nez-Maza, Otoniel
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01.09.1999; Elsevier
• Subjects: AIDS; AIDS/HIV; Biological and medical sciences; Biomarkers - blood; Burkitt Lymphoma - blood; Burkitt's; CD23 antigen; Hematologic and hematopoietic diseases; Human viral diseases; Humans; IL6; Infectious diseases; Interleukin-6 - blood; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; lymphoma; Lymphoma - etiology; Lymphoma - immunology; Lymphoma, AIDS-Related - blood; Lymphoma, Non-Hodgkin - blood; Male; Medical sciences; Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood; Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology; Receptors, IgE - blood; sCD23; Solubility; Time Factors; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Burkitt's; sCD23; AIDS; IL6; lymphoma; Human; Immunopathology; Pathogenesis; Cytokine; Burkitt lymphoma; Malignant hemopathy; B-Lymphocyte; Non Hodgkin lymphoma; Immune deficiency; Infection; Interleukin 6; Lymphoproliferative syndrome; Viral disease; Histological type; Complication
• ISSN: 1521-6616; 1521-7035
• DOI: 10.1006/clim.1999.4760

B cell hyperactivation accompanies HIV infection and is believed to contribute to the increased incidence of B cell lymphoma in persons with AIDS. To examine B cell activation which precedes the development of AIDS-associated lymphoma, we measured levels of two B cell stimulatory molecules, soluble CD23 (sCD23) and interleukin 6 (IL6), in the serum of HIV-infected individuals prior to the diagnosis of lymphoma. Serum sCD23 was elevated in those subjects who developed lymphoma, compared to AIDS, HIV+, and HIV− controls (P = 0.001). Serum IL6 was significantly elevated in subjects who developed Burkitt's/small noncleaved cell lymphoma (BL/SNC, P = 0.01), but not in those subjects who developed large cell, immunoblastic, or central nervous system lymphomas, compared to CD4-matched AIDS controls who did not have lymphoma. These results suggest that lymphomagenesis of the BL/SNC subtype of AIDS lymphoma reflects B cell hyperactivation of a different nature from that which precedes other subtypes of AIDS-associated B cell lymphoma.