Investigation of drift gas selectivity in high resolution ion mobility spectrometry with mass spectrometry detection

Recent studies in electrospray ionization (ESI)/ion mobility spectrometry (IMS) have focussed on employing different drift gases to alter separation efficiency for some molecules. This study investigates four structurally similar classes of molecules (cocaine and metabolites, amphetamines, benzodiaz...

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Bibliographic Details
Published inJournal of the American Society for Mass Spectrometry Vol. 13; no. 4; pp. 300 - 307
Main Authors Matz, Laura M, Hill, Herbert H, Beegle, Luther W, Kanik, Isik
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.04.2002
Elsevier Science
Springer Nature B.V
Subjects
Algorithms
Amphetamines
Amphetamines - chemistry
Analysis
Analytical chemistry
Benzodiazepines
Biological and medical sciences
Carbon dioxide
Chemistry
Cocaine - chemistry
Drift
Exact sciences and technology
Gases
Gases - chemistry
General pharmacology
Helium
Indicators and Reagents
Ionic mobility
Ionization
Ions
Mass spectrometry
Medical sciences
Metabolites
Molecular Weight
Peptides
Peptides - chemistry
Pharmacology. Drug treatments
Regression Analysis
Scientific imaging
Selectivity
Separation
Spectrometric and optical methods
Spectrometry, Mass, Electrospray Ionization - instrumentation
Spectroscopy
Amphetamine derivatives
Chemical analysis
Separation
Ion mobility
Peptides
Metabolite
Benzodiazepine derivatives
Cocaine
Mass spectrometry
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Summary:Recent studies in electrospray ionization (ESI)/ion mobility spectrometry (IMS) have focussed on employing different drift gases to alter separation efficiency for some molecules. This study investigates four structurally similar classes of molecules (cocaine and metabolites, amphetamines, benzodiazepines, and small peptides) to determine the effect of structure on relative mobility changes in four drift gases (helium, nitrogen, argon, carbon dioxide). Collision cross sections were plotted against drift gas polarizability and a linear relationship was found for the nineteen compounds evaluated in the study. Based on the reduced mobility database, all nineteen compounds could be separated in one of the four drift gases, however, the drift gas that provided optimal separation was specific for the two compounds.
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ISSN:1044-0305
1879-1123
DOI:10.1016/S1044-0305(01)00366-X