miR-590 promotes cell proliferation and invasion in T-cell acute lymphoblastic leukaemia by inhibiting RB1
MicroRNAs play important roles in the pathogenesis of cancers by inhibiting gene expression at posttranscriptional level. Here, we identified that miR-590 and its predicted target gene RB1 are differentially expressed in T-cell acute lymphoblastic leukaemia (T-ALL). The correlation between miR-590 a...
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| Published in | Oncotarget Vol. 7; no. 26; pp. 39527 - 39534 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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| Abstract | MicroRNAs play important roles in the pathogenesis of cancers by inhibiting gene expression at posttranscriptional level. Here, we identified that miR-590 and its predicted target gene RB1 are differentially expressed in T-cell acute lymphoblastic leukaemia (T-ALL). The correlation between miR-590 and RB1 was further confirmed in 395 T-ALL patients. In T-ALL cell lines, miR-590 promoted the cell proliferation by increasing G1/S transition. Moreover, migration and invasion assay showed that miR-590 promotes the migration and invasion of T-ALL cells by increasing E-cadherin and inhibiting MMP-9. Luciferase assays confirmed that miR-590 directly binds to the 3'untranslated region of RB1, and western blotting showed that miR-590 suppresses the expression of RB1 at the protein levels. This study indicated that miR-590 inhibits RB1 and promotes proliferation and invasion of T-ALL cells. Thus, miR-590 may represent a potential therapeutic target for T-ALL intervention. |
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| AbstractList | MicroRNAs play important roles in the pathogenesis of cancers by inhibiting gene expression at posttranscriptional level. Here, we identified that miR-590 and its predicted target gene RB1 are differentially expressed in T-cell acute lymphoblastic leukaemia (T-ALL). The correlation between miR-590 and RB1 was further confirmed in 395 T-ALL patients. In T-ALL cell lines, miR-590 promoted the cell proliferation by increasing G1/S transition. Moreover, migration and invasion assay showed that miR-590 promotes the migration and invasion of T-ALL cells by increasing E-cadherin and inhibiting MMP-9. Luciferase assays confirmed that miR-590 directly binds to the 3′untranslated region of RB1, and western blotting showed that miR-590 suppresses the expression of RB1 at the protein levels. This study indicated that miR-590 inhibits RB1 and promotes proliferation and invasion of T-ALL cells. Thus, miR-590 may represent a potential therapeutic target for T-ALL intervention. MicroRNAs play important roles in the pathogenesis of cancers by inhibiting gene expression at posttranscriptional level. Here, we identified that miR-590 and its predicted target gene RB1 are differentially expressed in T-cell acute lymphoblastic leukaemia (T-ALL). The correlation between miR-590 and RB1 was further confirmed in 395 T-ALL patients. In T-ALL cell lines, miR-590 promoted the cell proliferation by increasing G1/S transition. Moreover, migration and invasion assay showed that miR-590 promotes the migration and invasion of T-ALL cells by increasing E-cadherin and inhibiting MMP-9. Luciferase assays confirmed that miR-590 directly binds to the 3'untranslated region of RB1, and western blotting showed that miR-590 suppresses the expression of RB1 at the protein levels. This study indicated that miR-590 inhibits RB1 and promotes proliferation and invasion of T-ALL cells. Thus, miR-590 may represent a potential therapeutic target for T-ALL intervention.MicroRNAs play important roles in the pathogenesis of cancers by inhibiting gene expression at posttranscriptional level. Here, we identified that miR-590 and its predicted target gene RB1 are differentially expressed in T-cell acute lymphoblastic leukaemia (T-ALL). The correlation between miR-590 and RB1 was further confirmed in 395 T-ALL patients. In T-ALL cell lines, miR-590 promoted the cell proliferation by increasing G1/S transition. Moreover, migration and invasion assay showed that miR-590 promotes the migration and invasion of T-ALL cells by increasing E-cadherin and inhibiting MMP-9. Luciferase assays confirmed that miR-590 directly binds to the 3'untranslated region of RB1, and western blotting showed that miR-590 suppresses the expression of RB1 at the protein levels. This study indicated that miR-590 inhibits RB1 and promotes proliferation and invasion of T-ALL cells. Thus, miR-590 may represent a potential therapeutic target for T-ALL intervention. |
| Author | Ji, Xue-qiang Shao, Xue-jun Zhang, Hao Xu, Jun Zhu, Hong Miao, Mei-hua |
| AuthorAffiliation | 2 Department of Hematology, Affiliated Hospital of Jining Medical University, Jining, China 1 Department of Clinical Laboratory Diagnosis, Children's Hospital of Soochow University, Suzhou, China |
| AuthorAffiliation_xml | – name: 1 Department of Clinical Laboratory Diagnosis, Children's Hospital of Soochow University, Suzhou, China – name: 2 Department of Hematology, Affiliated Hospital of Jining Medical University, Jining, China |
| Author_xml | – sequence: 1 givenname: Mei-hua surname: Miao fullname: Miao, Mei-hua organization: Department of Clinical Laboratory Diagnosis, Children's Hospital of Soochow University, Suzhou, China – sequence: 2 givenname: Xue-qiang surname: Ji fullname: Ji, Xue-qiang organization: Department of Clinical Laboratory Diagnosis, Children's Hospital of Soochow University, Suzhou, China – sequence: 3 givenname: Hao surname: Zhang fullname: Zhang, Hao organization: Department of Hematology, Affiliated Hospital of Jining Medical University, Jining, China – sequence: 4 givenname: Jun surname: Xu fullname: Xu, Jun organization: Department of Clinical Laboratory Diagnosis, Children's Hospital of Soochow University, Suzhou, China – sequence: 5 givenname: Hong surname: Zhu fullname: Zhu, Hong organization: Department of Clinical Laboratory Diagnosis, Children's Hospital of Soochow University, Suzhou, China – sequence: 6 givenname: Xue-jun surname: Shao fullname: Shao, Xue-jun organization: Department of Clinical Laboratory Diagnosis, Children's Hospital of Soochow University, Suzhou, China |
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| Keywords | RB1 miR-590 cancer T-ALL |
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| Title | miR-590 promotes cell proliferation and invasion in T-cell acute lymphoblastic leukaemia by inhibiting RB1 |
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