Tumor microenvironment promotes lymphatic metastasis of cervical cancer: its mechanisms and clinical implications

Although previous studies have shed light on the etiology of cervical cancer, metastasis of advanced cervical cancer remains the main reason for the poor outcome and high cancer-related mortality rate. Cervical cancer cells closely communicate with immune cells recruited to the tumor microenvironmen...

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Published inFrontiers in oncology Vol. 13; p. 1114042
Main Authors Li, Yuting, Gao, Xiaofan, Huang, Yibao, Zhu, Xiaoran, Chen, Yingying, Xue, Liru, Zhu, Qingqing, Wang, Bo, Wu, Mingfu
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 10.05.2023
Subjects
cervical cancer
immune cells
lymphangiogenesis
lymphatic metastasis
Oncology
tumor microenvironment
lymphangiogenesis
immune cells
tumor microenvironment
cervical cancer
lymphatic metastasis
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Summary:Although previous studies have shed light on the etiology of cervical cancer, metastasis of advanced cervical cancer remains the main reason for the poor outcome and high cancer-related mortality rate. Cervical cancer cells closely communicate with immune cells recruited to the tumor microenvironment (TME), such as lymphocytes, tumor-associated macrophages, and myeloid-derived suppressor cells. The crosstalk between tumors and immune cells has been clearly shown to foster metastatic dissemination. Therefore, unraveling the mechanisms of tumor metastasis is crucial to develop more effective therapies. In this review, we interpret several characteristics of the TME that promote the lymphatic metastasis of cervical cancer, such as immune suppression and premetastatic niche formation. Furthermore, we summarize the complex interactions between tumor cells and immune cells within the TME, as well as potential therapeutic strategies to target the TME.
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Reviewed by: Luisa Pedro, The Open University, United Kingdom; Yael Raz Yana, University of California, Los Angeles, United States
Edited by: Tiziana Schioppa, University of Brescia, Italy
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2023.1114042