Hydrogen ion-coupled transport of D-glucose by phlorizin-sensitive sugar carrier in intestinal brush-border membranes

In rabbit intestinal brush-border membrane vesicles, Na+-independent D-glucose uptake in the presence of an inside-negative transmembrane potential was found to be stimulated by an imposed pH gradient. Na+-independent, pH-dependent and phlorizin-sensitive D-glucose-evoked potentials could be recorde...

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Published inBiochimica et biophysica acta Vol. 861; no. 3; pp. 483 - 488
Main Authors HOSHI, T, TAKUWA, N, ABE, M, TAJIMA, A
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier 23.10.1986
North-Holland
Subjects
Action Potentials
Animals
Applied sciences
Biological and medical sciences
Biological Transport
Cell physiology
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
Glucose - metabolism
Hydrogen-Ion Concentration
In Vitro Techniques
Intestinal Mucosa - metabolism
Membrane and intracellular transports
Microvilli - metabolism
Molecular and cellular biology
Monosaccharide Transport Proteins - physiology
Other techniques and industries
Phlorhizin - pharmacology
Potassium - pharmacology
Rabbits
Sodium - pharmacology
Ose
Brush border
Glucose
Membrane transport
Gut
Proton transport
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Summary:In rabbit intestinal brush-border membrane vesicles, Na+-independent D-glucose uptake in the presence of an inside-negative transmembrane potential was found to be stimulated by an imposed pH gradient. Na+-independent, pH-dependent and phlorizin-sensitive D-glucose-evoked potentials could be recorded from isolated toad intestine. The obtained data suggest that phlorizin-sensitive D-glucose carriers of intestinal brush-border membrane can interact with H+ when Na+ is absent.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0006-3002
1878-2434
DOI:10.1016/0005-2736(86)90458-X