Computer-aided diagnosis using embedded ensemble deep learning for multiclass drug-resistant tuberculosis classification

• Published in: Frontiers in medicine Vol. 10; p. 1122222
• Main Authors: Sethanan, Kanchana, Pitakaso, Rapeepan, Srichok, Thanatkij, Khonjun, Surajet, Weerayuth, Nantawatana, Prasitpuriprecha, Chutinun, Preeprem, Thanawadee, Jantama, Sirima Suvarnakuta, Gonwirat, Sarayut, Enkvetchakul, Prem, Kaewta, Chutchai, Nanthasamroeng, Natthapong
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 26.06.2023
• Subjects: artificial multiple intelligence system; computer aided diagnosis; drug resistant; ensemble deep learning; Medicine; tuberculosis; ensemble deep learning; computer aided diagnosis; artificial multiple intelligence system; tuberculosis; drug resistant
• ISSN: 2296-858X; 2296-858X
• DOI: 10.3389/fmed.2023.1122222

This study aims to develop a web application, TB-DRD-CXR, for the categorization of tuberculosis (TB) patients into subgroups based on their level of drug resistance. The application utilizes an ensemble deep learning model that classifies TB strains into five subtypes: drug sensitive tuberculosis (DS-TB), drug resistant TB (DR-TB), multidrug-resistant TB (MDR-TB), pre-extensively drug-resistant TB (pre-XDR-TB), and extensively drug-resistant TB (XDR-TB). The ensemble deep learning model employed in the TB-DRD-CXR web application incorporates novel fusion techniques, image segmentation, data augmentation, and various learning rate strategies. The performance of the proposed model is compared with state-of-the-art techniques and standard homogeneous CNN architectures documented in the literature. Computational results indicate that the suggested method outperforms existing methods reported in the literature, providing a 4.0%-33.9% increase in accuracy. Moreover, the proposed model demonstrates superior performance compared to standard CNN models, including DenseNet201, NASNetMobile, EfficientNetB7, EfficientNetV2B3, EfficientNetV2M, and ConvNeXtSmall, with accuracy improvements of 28.8%, 93.4%, 2.99%, 48.0%, 4.4%, and 7.6% respectively. The TB-DRD-CXR web application was developed and tested with 33 medical staff. The computational results showed a high accuracy rate of 96.7%, time-based efficiency (ET) of 4.16 goals/minutes, and an overall relative efficiency (ORE) of 100%. The system usability scale (SUS) score of the proposed application is 96.7%, indicating user satisfaction and a likelihood of recommending the TB-DRD-CXR application to others based on previous literature.