Effects of postoperative parenteral nutrition with different lipid emulsions in patients undergoing major abdominal surgery

• Published in: Annals of surgical treatment and research Vol. 91; no. 6; pp. 309 - 315
• Main Authors: Demirer, Seher, Sapmaz, Ali, Karaca, Ahmet Serdar, Kepenekci, Ilknur, Aydintug, Semih, Balci, Deniz, Sonyurek, Pinar, Kose, Kenan
• Format: Journal Article
• Language: English
• Published: Korea (South) 대한외과학회 01.12.2016; The Korean Surgical Society
• Subjects: Original; 일반외과학; Lipid emulsions; Inflammatory response; Total antioxidant status
• ISSN: 2288-6575; 2288-6796
• DOI: 10.4174/astr.2016.91.6.309

This study was designed to investigate the effects of total parenteral nutrition (PN) using different lipid emulsions in patients undergoing major abdominal surgery. Fifty-two patients were randomized to receive soybean oil + medium chain triglycerides (MCT) (group I), soybean oil + olive oil (group II), soybean oil + olive oil + fish oil (group III) as a lipid source. PN was started on postoperative day 1 and patients were maintained on PN for a minimum period of 4 days. Laboratory variables (CRP, prealbumin, transferrin) were measured before surgery and on postoperative days. Three treatment groups were included in the study. Patients in group I received long chain triglycerides (LCT) + LCT/MCT emulsion (%75 LCT + %25 LCT/MCT); Patients in group II received olive oil based emulsion (80% olive oil + 20% soybean oil, ClinOleic); Patients in group III received fish oil in addition to olive oil based emulsion (%85 ClinOleic + %15 Omegaven; Fresenius Kabi). The following 14 parameters were assessed: body weight, CRP, prealbumin, transferrin, tumor necrosis factor-α, interleukin-6, total antioxidant status, thiobarbituric acid reactive substances, oxidized low density lipoprotein-2, complete blood cell, international normalized ratio, D-dimer, activated partially thromboplastin time, prothrombin time. All other parameters showed no differences among the groups. The results of our trial demonstrate a potential beneficial effect of soybean oil/olive oil based lipid emulsions for use in PN regarding inflammatory response and oxidant capacity in the treatment of patients.