Tissue-Engineering the Intestine: The Trials before the Trials

• Published in: Cell stem cell Vol. 24; no. 6; pp. 855 - 859
• Main Authors: Clevers, Hans, Conder, Ryan K., Li, Vivian S.W., Lutolf, Matthias P., Vallier, Ludovic, Chan, Sarah, Grikscheit, Tracy C., Jensen, Kim B., De Coppi, Paolo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.06.2019
• Subjects: Animals; Cell Culture Techniques; Cell Differentiation; Cell Proliferation; Humans; Induced Pluripotent Stem Cells - pathology; Induced Pluripotent Stem Cells - physiology; Intestines - physiology; Organogenesis; Organoids - pathology; Organoids - physiology; Short Bowel Syndrome - therapy; Tissue Engineering - methods; Tissue Scaffolds

Building complex tissues requires the development of innovative interdisciplinary engineering solutions. In this Forum, the INTENS Consortium discuss experimental considerations and challenges for generating a tissue-engineered intestine for the treatment of short bowel syndrome, taking into account...