Tissue-Engineering the Intestine: The Trials before the Trials

• Published in: Cell stem cell Vol. 24; no. 6; pp. 855 - 859
• Main Authors: Clevers, Hans, Conder, Ryan K., Li, Vivian S.W., Lutolf, Matthias P., Vallier, Ludovic, Chan, Sarah, Grikscheit, Tracy C., Jensen, Kim B., De Coppi, Paolo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.06.2019
• Subjects: Animals; Cell Culture Techniques; Cell Differentiation; Cell Proliferation; Humans; Induced Pluripotent Stem Cells - pathology; Induced Pluripotent Stem Cells - physiology; Intestines - physiology; Organogenesis; Organoids - pathology; Organoids - physiology; Short Bowel Syndrome - therapy; Tissue Engineering - methods; Tissue Scaffolds
• ISSN: 1934-5909; 1875-9777
• DOI: 10.1016/j.stem.2019.04.018

Building complex tissues requires the development of innovative interdisciplinary engineering solutions. In this Forum, the INTENS Consortium discuss experimental considerations and challenges for generating a tissue-engineered intestine for the treatment of short bowel syndrome, taking into account cell source, scaffold choice, and design strategy for achieving proper assembly and function. Building complex tissues requires the development of innovative interdisciplinary engineering solutions. In this Forum, the INTENS Consortium discuss experimental considerations and challenges for generating a tissue-engineered intestine for the treatment of short bowel syndrome, taking into account cell source, scaffold choice, and design strategy for achieving proper assembly and function.