Proceedings of the Sleep and Epilepsy Workshop: Section 3 Mortality: Sleep, Night, and SUDEP

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy. Likely pathophysiological mechanisms include seizure-induced cardiac and respiratory dysregulation. A frequently identified feature in SUDEP cases is that they occur at night. This raises...

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Published inEpilepsy currents Vol. 21; no. 3; pp. 215 - 219
Main Authors Buchanan, Gordon F., Gluckman, Bruce J., Kalume, Franck K., Lhatoo, Samden, Maganti, Rama K., Noebels, Jeffrey L., Simeone, Kristina A., Quigg, Mark S., Pavlova, Milena K.
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.05.2021
Sage Publications Ltd
Subjects
Animal models
Epilepsy
Proceedings of the Sleep and Epilepsy Workshop
Seizures
Sleep
sleep
epilepsy
pathophysiological mechanisms
dysregulation
comorbidities
SUDEP
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Summary:Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy. Likely pathophysiological mechanisms include seizure-induced cardiac and respiratory dysregulation. A frequently identified feature in SUDEP cases is that they occur at night. This raises the question of a role for sleep state in regulating of SUDEP. An association with sleep has been identified in a number of studies with patients and in animal models. The focus of this section of the Sleep and Epilepsy Workshop was on identifying and understanding the role for sleep and time of day in the pathophysiology of SUDEP.
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ISSN:1535-7597
1535-7511
DOI:10.1177/15357597211004556