Towards practical sample preparation in point-of-care testing: user-friendly microfluidic devices

Microfluidic technologies offer a number of advantages for sample preparation in point-of-care testing (POCT), but the requirement for complicated external pumping systems limits their wide use. To facilitate sample preparation in POCT, various methods have been developed to operate microfluidic dev...

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Bibliographic Details
Published inLab on a chip Vol. 2; no. 7; pp. 1191 - 123
Main Authors Park, Juhwan, Han, Dong Hyun, Park, Je-Kyun
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 07.04.2020
Subjects
Actuation
Capillary pressure
Chemical reactions
Devices
Microchannels
Microfluidic devices
Point of care testing
Power sources
Pumping
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Summary:Microfluidic technologies offer a number of advantages for sample preparation in point-of-care testing (POCT), but the requirement for complicated external pumping systems limits their wide use. To facilitate sample preparation in POCT, various methods have been developed to operate microfluidic devices without complicated external pumping systems. In this review, we introduce an overview of user-friendly microfluidic devices for practical sample preparation in POCT, including self- and hand-operated microfluidic devices. Self-operated microfluidic devices exploit capillary force, vacuum-driven pressure, or gas-generating chemical reactions to apply pressure into microchannels, and hand-operated microfluidic devices utilize human power sources using simple equipment, including a syringe, pipette, or simply by using finger actuation. Furthermore, this review provides future perspectives to realize user-friendly integrated microfluidic circuits for wider applications with the integration of simple microfluidic valves. An overview and future perspectives of user-friendly microfluidic devices have been reported in terms of practical sample preparation in point-of-care testing.
Bibliography:Je-Kyun Park is a professor of bio and brain engineering at the Korea Advanced Institute of Science and Technology (KAIST). He received his Ph.D. degree in biotechnology from KAIST in 1992. Prior to joining the faculty at KAIST, he worked as a postdoctoral fellow (1996-1997) at the Johns Hopkins University and as Chief Research Engineer (1992-2002) at the LG Electronics Institute of Technology. He has co-authored more than 160 scientific papers in the field of lab-on-a-chip and microfluidic analytical technologies. He was also Conference Chair of μTAS 2015 and President (2016) of the Korean BioChip Society.
Dong Hyun Han received his B.S. degree in chemical and biomolecular engineering from the Korea Advanced Institute of Science and Technology (KAIST) in 2020. He is currently undertaking his M.S. degree in the Department of Bio and Brain Engineering at KAIST. His current research interests include microfluidics, lab-on-a-chip, and bioMEMS.
Juhwan Park received his B.S., M.S., and Ph.D. degrees in bio and brain engineering from the Korea Advanced Institute of Science and Technology (KAIST), in 2014, 2016, and 2020, respectively. His Ph.D. thesis was on a power-free microfluidic actuator for biological sample preparation and analysis in point-of-care testing (POCT) under the supervision of Prof. Je-Kyun Park. He is also interested in bioMEMS and lab-on-a-chip technologies for the development of cell-based assays. He received a Global Ph.D. Fellowship (2017-2019) from the National Research Foundation (NRF) of Korea.
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ISSN:1473-0197
1473-0189
1473-0189
DOI:10.1039/d0lc00047g