Synergistic chemotherapy/PTT/oxygen enrichment by multifunctional liposomal polydopamine nanoparticles for rheumatoid arthritis treatment

• Published in: Asian journal of pharmceutical sciences Vol. 19; no. 1; p. 100885
• Main Authors: Fu, Xiaoling, Song, Yutong, Feng, Xianquan, Liu, Zhihong, Gao, Wenhao, Song, Hongtao, Zhang, Qian
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2024; Elsevier
• Subjects: Oxygen generation; Photothermal therapy; Polydopamine; Rheumatoid arthritis; Thermosensitive liposomes; Photothermal therapy; Polydopamine; Thermosensitive liposomes; Oxygen generation; Rheumatoid arthritis
• ISSN: 1818-0876; 2221-285X
• DOI: 10.1016/j.ajps.2024.100885

Amultifunctional liposomal polydopamine nanoparticle (MPM@Lipo) was designed in this study, to combine chemotherapy, photothermal therapy (PTT) and oxygen enrichment to clear hyperproliferating inflammatory cells and improve the hypoxic microenvironment for rheumatoid arthritis (RA) treatment. MPM@Lipo significantly scavenged intracellular reactive oxygen species and relieved joint hypoxia, thus contributing to the repolarization of M1 macrophages into M2 phenotype. Furthermore, MPM@Lipo could accumulate at inflammatory joints, inhibit the production of inflammatory factors, and protect cartilage in vivo, effectively alleviating RA progression in a rat adjuvant-induced arthritis model. Moreover, upon laser irradiation, MPM@Lipo can elevate the temperature to not only significantly obliterate excessively proliferating inflammatory cells but also accelerate the production of methotrexate and oxygen, resulting in excellent RA treatment effects. Overall, the use of synergistic chemotherapy/PTT/oxygen enrichment therapy to treat RA is a powerful potential strategy. A multifunctional liposomal polydopamine nanoparticles (MPM@Lipo) was designed to combine chemotherapy, photothermal therapy and oxygen enrichment for RA treatment to clear hyperproliferative inflammatory cells and improve hypoxia microenvironment. The prepared MPM@Lipo accumulated selectively in adjuvant-induced arthritis (AIA) joints through the “ELVIS” effect and was phagocytosed by inflammatory cells, in which has a significantly therapeutic effect in AIA models. [Display omitted]