First synthesis and characterization of key stereoisomers related to Ezetimibe

uring the laboratory optimization and the late phase manufacturing studies of the cholesterol absorption inhibitor Ezetimibe 1, the formation of several stereoisomers was observed. To study the complete stereoisomer profile of Ezetimibe 1, we have synthesized and completely characterized several key...

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Bibliographic Details
Published inChinese chemical letters Vol. 25; no. 8; pp. 1157 - 1160
Main Authors Ren, Yun, Duan, Yan-Jun, Li, Ren-Jun, Deng, Yong, Hai, Li, Wu, Yong
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.08.2014
Subjects
Characterization
Ezetimibe
Related substances
Stereoisomers profile
Synthesis
参考标准
合成
实验室
抑制剂
立体异构体
胆固醇
表征
麦
Related substances
Characterization
Synthesis
Stereoisomers profile
Ezetimibe
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Summary:uring the laboratory optimization and the late phase manufacturing studies of the cholesterol absorption inhibitor Ezetimibe 1, the formation of several stereoisomers was observed. To study the complete stereoisomer profile of Ezetimibe 1, we have synthesized and completely characterized several key stereoisomers of Ezetimibe 1 for the first time. This study will provide an access to the reference standard of these stereoisomers and may have some implications in the development of new medicines.
Bibliography:uring the laboratory optimization and the late phase manufacturing studies of the cholesterol absorption inhibitor Ezetimibe 1, the formation of several stereoisomers was observed. To study the complete stereoisomer profile of Ezetimibe 1, we have synthesized and completely characterized several key stereoisomers of Ezetimibe 1 for the first time. This study will provide an access to the reference standard of these stereoisomers and may have some implications in the development of new medicines.
Ezetimibe ;Related substances; Stereoisomers profile ;Synthesis; Characterization
11-2710/O6
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2014.03.035