Anti-Phospholipid Antibodies in Cerebrospinal Fluid But Not Serum From a Boy With Psychosis

• Published in: Pediatric neurology Vol. 39; no. 4; pp. 293 - 294
• Main Authors: Sokol, Deborah K., PhD, MD, Chen, Lan S., MD, Wagenknecht, Dawn R., MS, McIntyre, John A., PhD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.10.2008; Elsevier
• Subjects: Antibodies, Antiphospholipid - cerebrospinal fluid; Antibodies, Antiphospholipid - immunology; Asperger Syndrome - cerebrospinal fluid; Asperger Syndrome - immunology; Biological and medical sciences; Child; Enzyme-Linked Immunosorbent Assay; Human viral diseases; Humans; Immunoglobulin G - cerebrospinal fluid; Immunoglobulin G - immunology; Infectious diseases; Intellectual Disability - cerebrospinal fluid; Intellectual Disability - immunology; Male; Medical sciences; Neurology; Pediatrics; Psychotic Disorders - cerebrospinal fluid; Psychotic Disorders - immunology; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Human; Psychosis; Phospholipid; Nervous system diseases; Cerebrospinal fluid; Child
• ISSN: 0887-8994; 1873-5150
• DOI: 10.1016/j.pediatrneurol.2008.07.008

A 12-year-old African American boy with mental retardation and Asperger's disorder presented with acute psychosis. Antiphospholipid antibody testing with enzyme-linked immunosorbent assay showed increased levels of immunoglobulin G anticardiolipin antibodies in the cerebrospinal fluid, but not in the serum. Although antiphospholipid antibodies have been reported in the serum of patients with thrombotic and neurologic disorders, there are only a few reports of these antibodies in cerebrospinal fluid. This finding is consistent with a recent report of antiphospholipid antibodies found in the cerebrospinal fluid of adults with acute psychosis.