Complete blood cell count-derived ratios can be useful biomarkers for neurological diseases

Complete blood cell count-derived parameters such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) have recently shown to be highly sensitive biomarkers. Their usefulness has been proven as prognostic factors in several cancers, in t...

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Published inInternational journal of immunopathology and pharmacology Vol. 35; p. 20587384211048264
Main Authors Novellino, Fabiana, Donato, Annalidia, Malara, Natalia, Madrigal, Jose LM, Donato, Giuseppe
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 2021
Sage Publications Ltd
Subjects
Biomarkers
Biomarkers - blood
Blood
Blood Cell Count - methods
Blood Platelets - pathology
Drug overdose
Humans
Inflammation
Letter to the Editor
Leukocyte Count - methods
Leukocytes (neutrophilic)
Lymphocyte Count - methods
Lymphocytes
Lymphocytes - pathology
Monocytes
Monocytes - pathology
Nervous system
Nervous System Diseases - blood
Nervous System Diseases - pathology
Neurological diseases
Neutrophils - pathology
Platelet Count - methods
Prognosis
platelet-to-lymphocyte ratio
psychiatrics
neutrophil-to-lymphocyte ratio
Blood cell count-derived ratios
lymphocyte-to-monocyte ratio
neurology
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Summary:Complete blood cell count-derived parameters such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) have recently shown to be highly sensitive biomarkers. Their usefulness has been proven as prognostic factors in several cancers, in the stratification of mortality in major cardiac events, as predictors and markers of infectious or inflammatory pathologies, and in many other conditions. Surprisingly, the study of these biomarkers in neurological diseases is somewhat limited. This paper aims to take stock of the data present in the literature regarding the complete blood cell count-derived ratios in this group of pathologies and to formulate a hypothesis, based on the most recent data concerning innate and acquired immunity, on which diseases of the nervous system could benefit in diagnostic and prognostic terms from the in-depth study of these new biomarkers.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ISSN:2058-7384
0394-6320
2058-7384
DOI:10.1177/20587384211048264