Are submicroscopic chromosomal inversions predisposing factors for the t(9;22)(q34;q11.2) translocation in chronic myeloid leukemia?

A complex chromosomal rearrangement observed in a patient with chronic myeloid leukemia was explained as the consequence of a multistep process. The explanation involved an initial t(9;22) translocation with breakpoints distant from the BCR and ABL1 genes followed by genomic deletions that produced...

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Published inMolecular cytogenetics Vol. 8; no. 1; p. 14
Main Authors González García, Juan Ramón, Cruz, Martín Daniel Domínguez, Gutiérrez, César Borjas
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 22.02.2015
BioMed Central
Subjects
Analysis
Care and treatment
Chronic myeloid leukemia
Genetic aspects
Letter to Editor
Risk factors
Submicroscopic inversion
Chronic myeloid leukemia
Non-allelic homologous recombination
t(9;22) translocation
Duplicons
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Summary:A complex chromosomal rearrangement observed in a patient with chronic myeloid leukemia was explained as the consequence of a multistep process. The explanation involved an initial t(9;22) translocation with breakpoints distant from the BCR and ABL1 genes followed by genomic deletions that produced the BCR-ABL1 hybrid gene. We present an alternative model that fits the origin of the patient's rearrangement better. The present model links submicroscopic inversions with the occurrence of the t(9;22) translocation and opens a new approach on the research on the disease.
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ISSN:1755-8166
1755-8166
DOI:10.1186/s13039-015-0116-9