Biglycan and reduced glycolysis are associated with breast cancer cell dormancy in the brain

Exit of quiescent disseminated cancer cells from dormancy is thought to be responsible for metastatic relapse and a better understanding of dormancy could pave the way for novel therapeutic approaches. We used an model of triple negative breast cancer brain metastasis to identify differences in tran...

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Published inFrontiers in oncology Vol. 13; p. 1191980
Main Authors Sunderland, Ashley, Williams, Jennifer, Andreou, Tereza, Rippaus, Nora, Fife, Christopher, James, Fiona, Kartika, Yolanda Dyah, Speirs, Valerie, Carr, Ian, Droop, Alastair, Lorger, Mihaela
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 29.06.2023
Subjects
biglycan
brain metastases
breast cancer
dormancy
glycolysis
Oncology
YAP
YAP
breast cancer
biglycan
brain metastases
dormancy
glycolysis
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Summary:Exit of quiescent disseminated cancer cells from dormancy is thought to be responsible for metastatic relapse and a better understanding of dormancy could pave the way for novel therapeutic approaches. We used an model of triple negative breast cancer brain metastasis to identify differences in transcriptional profiles between dormant and proliferating cancer cells in the brain. gene, encoding a small proteoglycan biglycan, was strongly upregulated in dormant cancer cells . expression was significantly downregulated in patient brain metastases as compared to the matched primary breast tumors and overexpression in cancer cells inhibited their growth and . Dormant cancer cells were further characterized by a reduced expression of glycolysis genes , and inhibition of glycolysis resulted in a reversible growth arrest reminiscent of dormancy. Our study identified mechanisms that could be targeted to induce/maintain cancer dormancy and thereby prevent metastatic relapse.
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Reviewed by: Monika Vishnoi, Houston Methodist Research Institute, United States; Ranjana Kumari Kanchan, University of Nebraska Medical Center, United States; Amanda Maree Clark, University of Pittsburgh, United States
Edited by: Panagiota S. Filippou, Teesside University, United Kingdom
Present address: Tereza Andreou, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2023.1191980