Salivary cortisol in early psychosis: New findings and meta-analysis

Highlights • No significant differences in basal salivary cortisol level between ultra-high risk subjects, first-episode of psychosis and help-seekers. • Meta-analyses show that only cortisol level in UHR was increased compared to controls. • Basal salivary cortisol may not be a valid biomarker for...

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Bibliographic Details
Published inPsychoneuroendocrinology Vol. 63; pp. 262 - 270
Main Authors Chaumette, Boris, Kebir, Oussama, Mam-Lam-Fook, Célia, Morvan, Yannick, Bourgin, Julie, Godsil, Bill P, Plaze, Marion, Gaillard, Raphaël, Jay, Thérèse M, Krebs, Marie-Odile
Format Journal Article
LanguageEnglish
Published England Elsevier 01.01.2016
Subjects
Adolescent
Adult
Age of Onset
Case-Control Studies
Cognitive science
Cohort Studies
Early Diagnosis
Endocrinology & Metabolism
Female
Humans
Hydrocortisone - metabolism
Hypothalamo-Hypophyseal System - metabolism
Hypothalamo-Hypophyseal System - physiopathology
Male
Neuropsychological Tests
Pituitary-Adrenal System - metabolism
Pituitary-Adrenal System - physiopathology
Psychiatry
Psychology
Psychotic Disorders - diagnosis
Psychotic Disorders - epidemiology
Psychotic Disorders - metabolism
Psychotic Disorders - pathology
Saliva - metabolism
Young Adult
Schizophrenia
First-episode psychosis
HPA axis
At-risk mental state
Ultra-high risk
Prodromal
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Summary:Highlights • No significant differences in basal salivary cortisol level between ultra-high risk subjects, first-episode of psychosis and help-seekers. • Meta-analyses show that only cortisol level in UHR was increased compared to controls. • Basal salivary cortisol may not be a valid biomarker for clinical staging/psychotic transition prediction.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2015.10.007