Interferon-mediated intracellular signalling Modulation of different phospholipase activities in Burkitt lymphoma cells

The effect of interferon-α on Daudi lymphoma cells either sensitive or resistant to the action of this cytokine has been analysed in terms of phospholipase C (PLC) and D (PLD) activities. Results have shown a combined modulation of PIP 2-specific phospholipase C and phospholipase D. In particular, a...

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Bibliographic Details
Published inFEBS letters Vol. 313; no. 3; pp. 210 - 212
Main Authors Cataldi, A., Rana, R., di Primio, R., Bareggi, R., Lisio, R., Toto, N., Miscia, S.
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 30.11.1992
Subjects
Burkitt Lymphoma - enzymology
Daudi cell
Diglycerides - metabolism
Humans
In Vitro Techniques
inositoltrisphosphate
Interferon
Interferon alpha-2
Interferon-alpha - pharmacology
IP3
less polar lipids
LPL
Phosphatidic Acids - metabolism
phosphatidic icid
phosphatidylinositol-bisphosphate
Phospholipase
Phospholipase D - metabolism
PIP2
Propranolol - pharmacology
Recombinant Proteins
Signal Transduction
Tumor Cells, Cultured
Type C Phospholipases - metabolism
PIP 2
Phospholipase
PA
Daudi cell
IP 3
LPL
Interferon
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Summary:The effect of interferon-α on Daudi lymphoma cells either sensitive or resistant to the action of this cytokine has been analysed in terms of phospholipase C (PLC) and D (PLD) activities. Results have shown a combined modulation of PIP 2-specific phospholipase C and phospholipase D. In particular, a decreased activity of PIP 2-specific PLC has been found, concomitant to a PLD-mediated phosphatidylcholine hydrolysis, suggesting that the intracellular signaling activated by interferon in Daudi cells involves a phospholipase D/phosphohydrolase pathway.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(92)81193-P