Effects of topiramate on weight and metabolism in children with epilepsy

• Published in: Acta Paediatrica Vol. 98; no. 9; pp. 1521 - 1525
• Main Authors: Li, Hai-feng, Zou, Yan, Xia, Zhe-zhi, Gao, Feng, Feng, Jian-hua, Yang, Cui-wei
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.09.2009; Blackwell
• Subjects: Adiponectin; Adiponectin - blood; Anti-Obesity Agents - therapeutic use; Biological and medical sciences; Blood Glucose; Body Mass Index; Body Weight - drug effects; Case-Control Studies; Child; Children; Epilepsy; Epilepsy - blood; Epilepsy - drug therapy; Epilepsy - metabolism; Female; Fructose - analogs & derivatives; Fructose - pharmacology; Fructose - therapeutic use; General aspects; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Homeostasis; Humans; Insulin - blood; Insulin Resistance; Leptin - blood; Lipids - blood; Male; Medical sciences; Metabolism - drug effects; Nervous system (semeiology, syndromes); Neurology; Statistics, Nonparametric; Topiramate; Human; Adipocytokine; Pediatrics; Topiramate; Nervous system diseases; Epilepsy; Body weight; Corporal biometry; Anticonvulsant; Metabolism; Cerebral disorder; Adiponectin; Central nervous system disease; Children; Child
• ISSN: 0803-5253; 1651-2227
• DOI: 10.1111/j.1651-2227.2009.01349.x

Aim:  To explore the mechanism of topiramate‐induced weight loss in epilepsy children by monitoring metabolism indices. Methods: Children with epilepsy were treated with topiramate at their first clinical visit. Metabolism indices including body mass index (BMI) and its SD scores, leptin, adiponectin, leptin/adiponectin (L/A), lipid profile‐insulin and Homeostasis Model Assessments (HOMA) index were collected before and after treatment. Results:  Topiramate treatment significantly reduced L/A (t = 2.156, p = 0.031), and markedly increased the serum level of adiponectin (t = 3.124, p = 0.002). Moreover, there were no relationships between the metabolism indices and dosages of topiramate (p > 0.05). Conclusion:  Our studies find that topiramate treatment in epilepsy children increases energy metabolism, resulting in weight loss. It has been demonstrated that adiponectin play a significant role in metabolic regulations.