Electrospun polyurethane and soy protein nanofibres for wound dressing applications

• Published in: IET nanobiotechnology Vol. 12; no. 2; pp. 94 - 98
• Main Authors: Sampath Kumar, Nithya, Santhosh, Chella, Vathaluru Sudakaran, Shruthi, Deb, Ananya, Raghavan, Vimala, Venugopal, Velmurugan, Bhatnagar, Amit, Bhat, Savithri, Andrews, Nirmala Grace
• Format: Journal Article
• Language: English
• Published: The Institution of Engineering and Technology 01.03.2018
• Subjects: biomedical materials; ciprofloxacin hydrochloride; contact angle; contact angle measurement; electrospinning; electrospun polyurethane nanofibres; Fourier transform infrared spectroscopy; Fourier transform spectra; II‐VI semiconductors; infrared spectra; mechanical properties; nanofabrication; nanofibre mat; nanofibres; nanomedicine; nanoparticles; nonallergic nanofibres; nonsensitizing nanofibres; nontoxic nanofibres; polymer fibres; scanning electron microscope; scanning electron microscopy; sessile drop test; soy protein isolate; soy protein nanofibres; Special Issue: 1st International Conference on Nanoscience and Nanotechnology (ICNAN 2016); thermal analysis; thermogravimetric analysis; toxicology; ultraviolet spectra; ultraviolet‐visible spectroscopy; universal testing machine; visible spectra; wavelength 300 nm to 350 nm; wettability; wetting; wide band gap semiconductors; wound dressing applications; wound healing material; wounds; X‐ray diffraction; zinc compounds; zinc oxide nanoparticles; ZnO; wavelength 300 nm to 350 nm; nanofabrication; soy protein nanofibres; X-ray diffraction; soy protein isolate; nontoxic nanofibres; scanning electron microscope; ultraviolet-visible spectroscopy; visible spectra; nanoparticles; electrospinning; electrospun polyurethane nanofibres; contact angle measurement; wettability; zinc compounds; nanofibre mat; thermal analysis; nanofibres; scanning electron microscopy; toxicology; sessile drop test; wounds; wetting; nonallergic nanofibres; nanomedicine; nonsensitizing nanofibres; wound healing material; contact angle; thermogravimetric analysis; polymer fibres; mechanical properties; ultraviolet spectra; II-VI semiconductors; zinc oxide nanoparticles; ciprofloxacin hydrochloride; biomedical materials; infrared spectra; Fourier transform spectra; Fourier transform infrared spectroscopy; ZnO; wide band gap semiconductors; wound dressing applications; universal testing machine
• ISSN: 1751-8741; 1751-875X; 1751-875X
• DOI: 10.1049/iet-nbt.2017.0022

In this report, a novel wound dressing material has been woven by electrospinning technique and tested for its various properties. For the nanofibre mat, a mixture of polyurethane (PU) and soy protein isolate (SPI) was electrospun in conjugation with zinc oxide nanoparticles (ZnO Nps) and ciprofloxacin hydrochloride (CipHCl) to produce fibrous mats viz. PU/SPI/ZnO and PU/SPI/CipHCl. An optimum ratio (1 : 1) of PU/SPI was used as suitable polymeric ratio in order to produce homogenous nanofibres without beads having an average diameter in the range of 300–350 nm. The electrospun nanofibre-based mats were characterised using X-ray diffraction, Fourier transform infrared spectroscopy, ultraviolet-visible spectroscopy, thermogravimetric analysis and scanning electron microscope. The mechanical properties of the nanofibrous mats were tested using universal testing machine. The wettability analysis was done using the contact angle measurement based on the sessile drop test. This study revealed that the electrospun PU/SPI-based nanofibres are non-sensitizing, non-allergic and non-toxic and that it can be used as a peculiar wound healing material.