Myocardial bridging as a common phenotype of hypertrophic cardiomyopathy has no effect on prognosis

• Published in: The American journal of the medical sciences Vol. 347; no. 6; p. 429
• Main Authors: Tian, Tao, Wang, Yi-Lu, Wang, Ji-Zheng, Sun, Kai, Zou, Yu-Bao, Zhang, Wei-Li, Zhu, Ling, Shen, Hu, Hui, Ru-Tai, Zhou, Xian-Liang, Song, Lei
• Format: Journal Article
• Language: English
• Published: United States 01.06.2014
• Subjects: Adult; Aged; Aged, 80 and over; Cardiomyopathy, Hypertrophic - diagnosis; Cardiomyopathy, Hypertrophic - epidemiology; Cohort Studies; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Bridging - diagnosis; Myocardial Bridging - epidemiology; Phenotype; Prognosis; Retrospective Studies; Young Adult
• ISSN: 1538-2990
• DOI: 10.1097/MAJ.0000000000000194

The prognostic significance of myocardial bridging in hypertrophic cardiomyopathy (HCM) remains controversial. This investigation sought to evaluate the impact of myocardial bridging on prognosis of patients with HCM. A total of 298 adult patients (73% male, mean age, 53 ± 12 years) with HCM were retrospectively enrolled at Fuwai Hospital from 1999 to 2011. Myocardial bridging was evaluated by coronary angiography. Follow-up data were collected by telephone interviews and mailed questionnaires. Thirty-four (11%, 34/298) patients were determined with myocardial bridging and the middle of left anterior descending artery was the most frequently involved segment (77%, 26/34). Patients with myocardial bridging were younger than those without bridging (48 ± 9 versus 54 ± 12 years, P = 0.001). During the follow-up of 4.2 ± 2.3 years (range, 0.7-12.2 years), the presence of myocardial bridging was not evidently associated with increased risk for all-cause death (P = 0.54), cardiovascular death (P = 0.60), sudden cardiac death (P = 0.53) and deterioration of heart failure (P = 0.84). Myocardial bridging was a relatively common morphological component of HCM but not a predictor for adverse clinical outcomes.