Epstein-Barr virus-associated T/natural killer-cell lymphomas in the elderly: The first consensus meeting in Kofu 2013

• Published in: Journal of dermatology Vol. 41; no. 1; pp. 40 - 42
• Main Authors: Hamada, Toshihisa, Nakamura, Shigeo, Ko, Young-Hyeh, Yoshino, Tadashi, Ohshima, Koichi, Matsuzawa, Takamitsu, Miura, Keiko, Takahashi, Toshifumi, Nomura, Hisashi, Hoshino, Tomomi, Suzuki, Daisuke, Shimada, Shinji, Iwatsuki, Keiji
• Format: Conference Proceeding Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.01.2014; Wiley Subscription Services, Inc
• Subjects: Aged; Aged, 80 and over; centroblastoid; Epstein-Barr virus; Epstein-Barr Virus Infections - complications; Epstein-Barr Virus Infections - pathology; Humans; hydroa vacciniforme; Lymphoma - pathology; Lymphoma - virology; nasal type; Skin - pathology; T/natural killer-cell lymphoma; hydroa vacciniforme; T/natural killer-cell lymphoma; Epstein-Barr virus; nasal type; centroblastoid
• ISSN: 0385-2407; 1346-8138
• DOI: 10.1111/1346-8138.12373

From a clinicopathological conference on nine elderly patients with Epstein–Barr virus (EBV)‐associated T/natural killer (NK)‐cell lymphoma, we have addressed the patients' backgrounds, clinical manifestations, histopathological findings, cytogenesis, complications and prognoses. Among these elderly patients (>65 years old), seven patients had extranodal NK/T‐cell lymphoma, nasal type (ENKL) with an NK‐cell phenotype, and two patients had EBV+ T‐cell lymphomas or lymphoproliferative disorders (LPD) with cutaneous lesions mimicking pityriasis lichenoides et varioliformis acuta (PLEVA) or hydroa vacciniforme (HV). No patients had a previous episode of EBV‐related symptoms such as infectious mononucleosis, chronic active EBV infection, HV or hypersensitivity to mosquito bites. Elderly patients with ENKL may show the centroblastoid variant. EBV+CD8+CD56+/− lymphocytes may be responsible for the development of PLEVA or HV‐like cutaneous lesions in the elderly.