Evolution of lesion volume in acute stroke treated by intravenous t-PA
Purpose To determine the evolution of the ischemic lesion volumes in a population treated with tissue plasminogen activator (t‐PA), MRIs were performed before treatment and 24 hours later; final infarct size was evaluated 60 days later. Materials and Methods A total of 42 patients with hemispheric s...
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Published in | Journal of magnetic resonance imaging Vol. 22; no. 1; pp. 23 - 28 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.07.2005
Wiley-Blackwell |
Subjects | |
Online Access | Get full text |
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Summary: | Purpose
To determine the evolution of the ischemic lesion volumes in a population treated with tissue plasminogen activator (t‐PA), MRIs were performed before treatment and 24 hours later; final infarct size was evaluated 60 days later.
Materials and Methods
A total of 42 patients with hemispheric stroke were recruited for a thrombolytic study. Intravenous t‐PA was given after MRI within the first seven hours after stroke onset. Volumes were evaluated on day 0 and day 1 with diffusion‐weighted imaging (DWI), on day 60 with T2‐weighted imaging (T2WI), and recanalization was assessed based on day 1 MR angiography (MRA).
Results
Lesion volume increased between day 0 and day 1, and decreased between day 1 and day 60. It was lower in the group of patients with recanalization on day 1 MRA.
Conclusion
Volume analysis emphasizes the effectiveness of recanalization as a predictive factor for better outcome, based on final infarct size. The decrease in lesion volumes between day 1 and day 60 suggests that other factors leads to overestimation of day 1 abnormal diffusion volume. This could explain the delayed partial reversibility of the DWI abnormality. J. Magn. Reson. Imaging 2005;22:23–28. © 2005 Wiley‐Liss, Inc. |
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Bibliography: | istex:D4D87F6F661A02E2041D2414AE520547A3B23200 ark:/67375/WNG-MRPLF377-2 ArticleID:JMRI20363 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 1053-1807 1522-2586 |
DOI: | 10.1002/jmri.20363 |