Novel 28-kDa secretory protein from rat olfactory epithelium

• Published in: FEBS letters Vol. 381; no. 1; pp. 12 - 14
• Main Authors: Peshenko, I.V., Novoselov, V.I., Evdokimov, V.A., Nikolaev, Yu.V., Shuvaeva, T.M., Lipkin, V.M., Fesenko, E.E.
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 26.02.1996
• Subjects: 28-kDa protein; Amino Acid Sequence; Animals; Antibodies; Cattle; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Epithelium - metabolism; Glutathione; Glutathione peroxidase; Glutathione Peroxidase - biosynthesis; Glutathione Peroxidase - chemistry; Glutathione Peroxidase - isolation & purification; Isoenzymes - biosynthesis; Isoenzymes - chemistry; Isoenzymes - isolation & purification; Methionine - metabolism; Molecular Sequence Data; Molecular Weight; Olfactory epithelium; Olfactory Mucosa - metabolism; Organ Specificity; Rabbits - immunology; Rat; Rats; Sequence Homology, Amino Acid; Sulfur Radioisotopes; Glutathione peroxidase; 28-kDa protein; Rat; Olfactory epithelium; Glutathione
• ISSN: 0014-5793; 1873-3468
• DOI: 10.1016/0014-5793(96)00071-3

We have isolated a novel secretory 28-kDa protein which is an abundant component of the rat olfactory mucosa. The partial sequence of the 28-kDa protein has been determined. The amino acid sequence of the 28-kDa protein is similar to that of non-selenium glutathione peroxidase from bovine ciliary body. The 28-kDa protein catalyzed decomposition of the hydrogen peroxide as well as organic hydroperoxides by reduced glutathion and seems to be a member of the glutathion peroxidases family.