Carcinoma of the larynx with mucosubstance production and neuroendocrine differentiation: An ultrastructural and immunohistochemical study

Primary neuroendocrine tumors of the larynx appear to be extremely rare. We report a case of well‐differentiated neuroendocrine carcinoma arising in the larynx of a 61‐year‐old white woman. This case was initially diagnosed as a lymph node metastasis in the neck from an unknown primary carcinoma. Ex...

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Published inCancer Vol. 49; no. 2; pp. 343 - 349
Main Authors Paladugu, Rao R., Nathwani, Bharat N., Goodstein, Jordan, Dardi, Loren E., Memoli, Vincent E., Gould, Victor E.
Format Journal Article
LanguageEnglish
Published New York Wiley Subscription Services, Inc., A Wiley Company 15.01.1982
Subjects
Adrenocorticotropic Hormone - analysis
Apudoma - pathology
Calcitonin - analysis
Carcinoid Tumor - pathology
Carcinoid Tumor - surgery
Carcinoid Tumor - ultrastructure
Cytoplasmic Granules - ultrastructure
Female
Histocytochemistry
Humans
Laryngeal Neoplasms - pathology
Laryngeal Neoplasms - surgery
Laryngeal Neoplasms - ultrastructure
Lymph Nodes - ultrastructure
Lymphatic Metastasis
Middle Aged
Neck Dissection
Somatostatin - analysis
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Summary:Primary neuroendocrine tumors of the larynx appear to be extremely rare. We report a case of well‐differentiated neuroendocrine carcinoma arising in the larynx of a 61‐year‐old white woman. This case was initially diagnosed as a lymph node metastasis in the neck from an unknown primary carcinoma. Extensive workup subsequently revealed that the larynx was the primary site of the tumor. An electron microscopic study of both the primary and metastatic tumors showed numerous neurosecretory‐type granules. Immunohistochemical studies revealed positive immunoreactivity against calcitonin, somatostatin, and ACTH. However, the tumor also displayed focal exocrine differentiation and mucosubstance production. The patient underwent a supraglottic laryngectomy and radical neck dissection and was free of tumor 22 months postoperatively.
Bibliography:Resident in Pathology, Rush Medical College.
Pathologist, City of Hope National Medical Center, and Associate Clinical Professor, Department of Pathology, University of California at Los Angeles Medical Center.
Instructor in Pathology, Rush Medical College.
Pathologist, City of Hope National Medical Center, and Clinical Professor of Pathology, University of Southern California School of Medicine.
Professor and Vice‐Chairman of Pathology, Rush Medical College and Rush‐Presbyterian‐St. Luke's Medical Center.
Surgeon, Department of General and Oncologic Surgery, City of Hope National Medical Center.
ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
ObjectType-Article-3
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19820115)49:2<343::AID-CNCR2820490222>3.0.CO;2-T