Ets-1 is up-regulated together with its target gene products matrix metalloproteinase-2 and matrix metalloproteinase-9 in atypical and anaplastic meningiomas

• Published in: Histopathology Vol. 48; no. 7; pp. 836 - 845
• Main Authors: Okuducu, A F, Zils, U, Michaelis, S A M, Michaelides, S, Von Deimling, A
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.2006; Blackwell
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Ets-1; Female; Humans; Immunohistochemistry; Investigative techniques, diagnostic techniques (general aspects); Male; matrix metalloproteinase; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 9 - metabolism; Medical sciences; Meningeal Neoplasms - metabolism; Meningeal Neoplasms - pathology; meningioma; Meningioma - metabolism; Meningioma - pathology; Middle Aged; Neoplasm Invasiveness; Neurology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; prognosis; Proto-Oncogene Protein c-ets-1 - metabolism; Tumors of the nervous system. Phacomatoses; Up-Regulation; meningioma; Nervous system diseases; Targeting; Transcription factor Ets1; Enzyme; Gene product; Metalloendopeptidases; Malignant meningioma; Ets-1; Malignant tumor; prognosis; Gelatinase A; Peptidases; Anatomic pathology; Regulation(control); Hydrolases; matrix metalloproteinase; Atypical
• ISSN: 0309-0167; 1365-2559
• DOI: 10.1111/j.1365-2559.2006.02432.x

Aims : Matrix metalloproteinases (MMPs) are a pivotal enzyme system involved in extracellular matrix (ECM) degradation and are considered to be important in the development and invasion of human tumours. Little is known about the regulation of MMPs in meningioma development and prognosis. The transcription factor Ets‐1 is the main regulator of several MMPs, including MMP‐2 and ‐9. The aim of this study was to determine the relationship between the expression of Ets‐1, MMP‐2 and ‐9 and the malignant potential of meningiomas. Methods and results : Seventy‐four meningiomas of different histological grades were investigated immunohistochemically. Up‐regulation of Ets‐1, MMP‐2 and MMP‐9 expression was observed in atypical and anaplastic meningiomas. Invasive meningiomas showed increased immunohistochemical expression of these proteins compared with non‐invasive meningiomas. We also observed a correlation between the expression of Ets‐1 and of its target genes MMP‐2 and MMP‐9. Conclusions : Ets‐1 may be involved in the transcriptional regulation of MMP‐2 and MMP‐9 as well as in the invasive process in meningiomas. Evaluation of these expressions might be of prognostic value for meningiomas.