Neurotrophin-3 gene polymorphism associated with schizophrenia

The recent possible neurodevelopmental etiology of schizophrenia makes the neurotrophin-3 (NT-3) gene an interesting candidate locus. We studied the allelic distributions of dinucleotide repeat polymorphism at the NT-3 gene locus in 70 patients with schizophrenia and in 70 controls. A highly signifi...

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Bibliographic Details
Published inActa psychiatrica Scandinavica Vol. 89; no. 6; p. 390
Main Authors Nanko, S, Hattori, M, Kuwata, S, Sasaki, T, Fukuda, R, Dai, X Y, Yamaguchi, K, Shibata, Y, Kazamatsuri, H
Format Journal Article
LanguageEnglish
Published United States 01.06.1994
Subjects
Adult
Alleles
DNA - analysis
Female
Genotype
Humans
Male
Middle Aged
Nerve Growth Factors - genetics
Neurotrophin 3
Polymerase Chain Reaction
Polymorphism, Genetic
Schizophrenia - genetics
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Summary:The recent possible neurodevelopmental etiology of schizophrenia makes the neurotrophin-3 (NT-3) gene an interesting candidate locus. We studied the allelic distributions of dinucleotide repeat polymorphism at the NT-3 gene locus in 70 patients with schizophrenia and in 70 controls. A highly significant difference between the two groups was observed at the allele A3. Even Bonferroni's correction was used, the difference was still significant. Individuals with homozygous or heterozygous for the allele A3 had a 2.4-fold increased risk of schizophrenia. Determination of NT-3 genotype may help to identify those at greater risk of schizophrenia. Furthermore, this finding supports evidence implicating neurodevelopmental deficit in the pathogenesis of this disorder.
ISSN:0001-690X
DOI:10.1111/j.1600-0447.1994.tb01534.x