Mucormycosis Mimicks Sinusitis in a Diabetic Adult

• Published in: Annals of the New York Academy of Sciences Vol. 1084; no. 1; pp. 520 - 530
• Main Authors: SZALAI, GYÖRGY, FELLEGI, VERONIKA, SZABÓ, ZSUZSANNA, VITÉZ, LAJOS CSOKONAI
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.11.2006
• Subjects: Adult; Amphotericin B - therapeutic use; Antifungal Agents - therapeutic use; cranial bone mucormycosis; Diabetes Mellitus, Type 1 - complications; Diabetic Nephropathies; Diagnosis, Differential; Humans; immunosuppression; Male; Mucormycosis - diagnosis; Mucormycosis - drug therapy; Sinusitis - diagnosis; Sinusitis - diagnostic imaging; surgical debridement; Tomography, X-Ray Computed
• ISSN: 0077-8923; 1749-6632; 1930-6547
• DOI: 10.1196/annals.1372.010

:  Fungal sinusitis caused by invasive fungal infections, such as Mucormycosis, occurs predominantly in an immunocompromised patient. However, invasive cranial bone mycoses are rare and are usually associated with host immunodeficiency. They are difficult to diagnose, and in many cases are fatal. Treatment consists of antifungal chemotherapy, radical surgical debridement, and control of the underlying immunological condition. We report a case of Mucormycosis in a patient with type 1 diabetes mellitus. The patient had a history of dental pathology and associated renal dysfunction. The patient was managed by extensive surgical debridement followed by amphotericin B lipid complex injection (Abelcet 5 mg/bw kg/day) as an antifungal agent. Our patient's ocular function was affected. The radical treatment and follow‐up by a multidisciplinary team eliminated the mucor‐related consequences, however, the patient died because of end‐stage renal failure. In conclusion, type 1 diabetes may be associated with invasive fungal sinusitis.