Marine microorganisms as a promising and sustainable source of bioactive molecules

• Published in: Marine environmental research Vol. 128; pp. 58 - 69
• Main Authors: Romano, G., Costantini, M., Sansone, C., Lauritano, C., Ruocco, N., Ianora, A.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2017; Elsevier BV
• Subjects: Antibiotics; Aquatic habitats; Aquatic Organisms; Bacteria; Biocompatibility; Biological Products; Biology; Biotechnology; Blue growth; Cancer; Conservation of Natural Resources; Cultivation; Cultivation methods; Drug discovery; Drugs; Ecosystem; Exploitation; Industry; Marine Biology; Marine microorganisms; Marine natural products; Marine organisms; Marine resources; Microalgae; Microorganisms; Molecular biology; Molecular biology approaches; Neurodegeneration; Pharmaceutical industry; Pharmaceuticals; Studies; Water Microbiology; Marine natural products; Bacteria; Blue growth; Microalgae; Drug discovery; Cultivation methods; Molecular biology approaches
• ISSN: 0141-1136; 1879-0291
• DOI: 10.1016/j.marenvres.2016.05.002

There is an urgent need to discover new drug entities due to the increased incidence of severe diseases as cancer and neurodegenerative pathologies, and reducing efficacy of existing antibiotics. Recently, there is a renewed interest in exploring the marine habitat for new pharmaceuticals also thanks to the advancement in cultivation technologies and in molecular biology techniques. Microorganisms represent a still poorly explored resource for drug discovery. The possibility of obtaining a continuous source of bioactives from marine microorganisms, more amenable to culturing compared to macro-organisms, may be able to meet the challenging demands of pharmaceutical industries. This would enable a more environmentally-friendly approach to drug discovery and overcome the over-utilization of marine resources and the use of destructive collection practices. The importance of the topic is underlined by the number of EU projects funded aimed at improving the exploitation of marine organisms for drug discovery. •Marine microorganisms are a new and poorly explored source for the discovery of novel bioactives.•Advances in cultivation and molecular biology contribute to marine drug discovery.•Omics tools allow the identification of bioactives in uncultivable species.•Novel ocean medicines represent the most exciting new directions of marine science.