Novel Synthetic Monothiourea Aspirin Derivatives Bearing Alkylated Amines as Potential Antimicrobial Agents

A new series of aspirin bearing alkylated amines moieties 1–12 were synthesised by reacting isothiocyanate with a series of aniline derivatives in overall yield of 16–56%. The proposed structures of all the synthesised compounds were confirmed using elemental analysis, FTIR, and 1H and 13C NMR spect...

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Bibliographic Details
Published inJournal of chemistry Vol. 2017; no. 2017; pp. 1 - 7
Main Authors Ngaini, Zainab, Abd Halim, Ainaa Nadiah, Choi, Ching Liang, Tan, Bee Ling, Chai, Tchan Wei, Nordin, Norsyafikah Asyilla, Hussain, Mohd Hasnain Md
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2017
Hindawi
John Wiley & Sons, Inc
Hindawi Limited
Subjects
Anti-infective agents
Aspirin
Materials
Organic compounds
Pharmaceutical research
Synthesis
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Summary:A new series of aspirin bearing alkylated amines moieties 1–12 were synthesised by reacting isothiocyanate with a series of aniline derivatives in overall yield of 16–56%. The proposed structures of all the synthesised compounds were confirmed using elemental analysis, FTIR, and 1H and 13C NMR spectroscopy. All compounds were evaluated for antibacterial activities against E. coli and S. aureus via turbidimetric kinetic and Kirby Bauer disc diffusion method. Compound 5 bearing meta -CH3 substituent showed the highest relative inhibition zone diameter against tested bacteria compared to ortho and para substituent. Furthermore, aspirin derivatives bearing shorter chains exhibited better bacterial inhibition than longer alkyl chains.
ISSN:2090-9063
2090-9071
DOI:10.1155/2017/2378186