The Relationship Between Diabetes Mellitus and Cancers and Its Underlying Mechanisms

Epidemiological studies suggest associations between diabetes mellitus and some cancers. The risk of a number of cancers appears to be increased in diabetes mellitus. On the other hand, some cancer and cancer therapies could lead to diabetes mellitus. Genetic factors, obesity, inflammation, oxidativ...

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Published inFrontiers in endocrinology (Lausanne) Vol. 13; p. 800995
Main Authors Zhu, Bing, Qu, Shen
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 11.02.2022
Subjects
cancers
Diabetes Mellitus, Type 2 - drug therapy
Endocrinology
Humans
Hyperglycemia
Hyperinsulinism
Insulin - therapeutic use
mechanism
Neoplasms - complications
Neoplasms - epidemiology
type 1 diabetes
type 2 diabetes (T2D)
type 3C diabetes mellitus
cancers
type 1 diabetes
mechanism
type 2 diabetes (T2D)
type 3C diabetes mellitus
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Summary:Epidemiological studies suggest associations between diabetes mellitus and some cancers. The risk of a number of cancers appears to be increased in diabetes mellitus. On the other hand, some cancer and cancer therapies could lead to diabetes mellitus. Genetic factors, obesity, inflammation, oxidative stress, hyperglycemia, hyperinsulinemia, cancer therapies, insulin and some oral hypoglycemic drugs appear to play a role in the crosstalk between diabetes mellitus and cancers. This review summarized the associations between various types of diabetes and cancers and updated available evidence of underlying mechanisms between diabetes and cancers.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Reviewed by: Ferdinando Carlo Sasso, Università della Campania Luigi Vanvitelli, Italy; Lin Liao, Shandong University, China
Edited by: Martin Heni, University of Tübingen, Germany
This article was submitted to Clinical Diabetes, a section of the journal Frontiers in Endocrinology
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2022.800995