Applications of Protein Microarrays in Biomarker Discovery for Autoimmune Diseases

Dysregulated autoantibodies and cytokines were deemed to provide important cues for potential illnesses, such as various carcinomas and autoimmune diseases. Increasing biotechnological approaches have been applied to screen and identify the specific alterations of these biomolecules as distinctive b...

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Published inFrontiers in immunology Vol. 12; p. 645632
Main Authors Li, Siting, Song, Guang, Bai, Yina, Song, Ning, Zhao, Jiuliang, Liu, Jian, Hu, Chaojun
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 03.05.2021
Subjects
autoimmune disease
biomarker discovery
experimental design
Immunology
protein microarray
proteome
experimental design
autoimmune disease
biomarker discovery
protein microarray
proteome
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Summary:Dysregulated autoantibodies and cytokines were deemed to provide important cues for potential illnesses, such as various carcinomas and autoimmune diseases. Increasing biotechnological approaches have been applied to screen and identify the specific alterations of these biomolecules as distinctive biomarkers in diseases, especially autoimmune diseases. As a versatile and robust platform, protein microarray technology allows researchers to easily profile dysregulated autoantibodies and cytokines associated with autoimmune diseases using various biological specimens, mainly serum samples. Here, we summarize the applications of protein microarrays in biomarker discovery for autoimmune diseases. In addition, the key issues in the process of using this approach are presented for improving future studies.
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Reviewed by: Richard David Leslie, Queen Mary University of London, United Kingdom; Robert Nagele, Rowan University, United States
These authors have contributed equally to this work and share first authorship
This article was submitted to Autoimmune and Autoinflammatory Disorders, a section of the journal Frontiers in Immunology
Edited by: James A. Lederer, Brigham and Women's Hospital and Harvard Medical School, United States
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2021.645632