Gut Microbiota: An Important Player in Type 2 Diabetes Mellitus

Type 2 diabetes mellitus (T2DM) is one of the common metabolic diseases in the world. Due to the rise in morbidity and mortality, it has become a global health problem. To date, T2DM still cannot be cured, and its intervention measures mainly focus on glucose control as well as the prevention and tr...

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Published inFrontiers in cellular and infection microbiology Vol. 12; p. 834485
Main Authors Zhou, Zheng, Sun, Bao, Yu, Dongsheng, Zhu, Chunsheng
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 15.02.2022
Subjects
Cellular and Infection Microbiology
glucose metabolism
gut microbiota
insulin resistance
pathogenesis
type 2 diabetes mellitus
type 2 diabetes mellitus
pathogenesis
glucose metabolism
insulin resistance
gut microbiota
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Summary:Type 2 diabetes mellitus (T2DM) is one of the common metabolic diseases in the world. Due to the rise in morbidity and mortality, it has become a global health problem. To date, T2DM still cannot be cured, and its intervention measures mainly focus on glucose control as well as the prevention and treatment of related complications. Interestingly, the gut microbiota plays an important role in the development of metabolic diseases, especially T2DM. In this review, we introduce the characteristics of the gut microbiota in T2DM population, T2DM animal models, and diabetic complications. In addition, we describe the molecular mechanisms linking host and the gut microbiota in T2DM, including the host molecules that induce gut microbiota dysbiosis, immune and inflammatory responses, and gut microbial metabolites involved in pathogenesis. These findings suggest that we can treat T2DM and its complications by remodeling the gut microbiota through interventions such as drugs, probiotics, prebiotics, fecal microbiota transplantation (FMT) and diets.
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Reviewed by: Kanthida Kusonmano, King Mongkut’s University of Technology Thonburi, Thailand; Yotsawat Pomyen, Chulabhorn Research Institute, Thailand
These authors have contributed equally to this work
Edited by: Intawat Nookaew, University of Arkansas for Medical Sciences, United States
This article was submitted to Microbiome in Health and Disease, a section of the journal Frontiers in Cellular and Infection Microbiology
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2022.834485