Advances in Metagenomics and Its Application in Environmental Microorganisms

Metagenomics is a new approach to study microorganisms obtained from a specific environment by functional gene screening or sequencing analysis. Metagenomics studies focus on microbial diversity, community constitute, genetic and evolutionary relationships, functional activities, and interactions an...

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Published inFrontiers in microbiology Vol. 12; p. 766364
Main Authors Zhang, Lu, Chen, FengXin, Zeng, Zhan, Xu, Mengjiao, Sun, Fangfang, Yang, Liu, Bi, Xiaoyue, Lin, Yanjie, Gao, YuanJiao, Hao, HongXiao, Yi, Wei, Li, Minghui, Xie, Yao
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 17.12.2021
Subjects
antibiotics resistance genes
bioremediation
metagenomics
Microbiology
next-generation sequencing
shotgun sequencing
third generation sequencing
antibiotics resistance genes
shotgun sequencing
bioremediation
next-generation sequencing
third generation sequencing
metagenomics
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Summary:Metagenomics is a new approach to study microorganisms obtained from a specific environment by functional gene screening or sequencing analysis. Metagenomics studies focus on microbial diversity, community constitute, genetic and evolutionary relationships, functional activities, and interactions and relationships with the environment. Sequencing technologies have evolved from shotgun sequencing to high-throughput, next-generation sequencing (NGS), and third-generation sequencing (TGS). NGS and TGS have shown the advantage of rapid detection of pathogenic microorganisms. With the help of new algorithms, we can better perform the taxonomic profiling and gene prediction of microbial species. Functional metagenomics is helpful to screen new bioactive substances and new functional genes from microorganisms and microbial metabolites. In this article, basic steps, classification, and applications of metagenomics are reviewed.
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These authors have contributed equally to this work
This article was submitted to Food Microbiology, a section of the journal Frontiers in Microbiology
Edited by: Xuejun Ma, Chinese Center for Disease Control and Prevention, China
Reviewed by: Xiyang Wu, Jinan University, China; Ahmed Abd El Wahed, Leipzig University, Germany
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2021.766364