One-pot synthesis of pyrido[2,3-d]pyrimidine derivatives using sulfonic acid functionalized SBA-15 and the study on their antimicrobial activities

A simple and clean one-pot method for the preparation of 7-amino-2,4-dioxo-5-aryl-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile derivatives using 6-amino uracil, various aromatic aldehydes and malononitrile in the presence of sulfonic acid functionalized SBA-15 (SBA-Pr-SO3H) is described....

Full description

Saved in:
Bibliographic Details
Published inJournal of Saudi Chemical Society Vol. 19; no. 6; pp. 676 - 681
Main Authors Mohammadi Ziarani, Ghodsi, Hosseini Nasab, Narges, Rahimifard, Mahshid, Abolhasani Soorki, Ali
Format Journal Article
LanguageEnglish
Published Riyadh, Saudi Arabia Elsevier B.V 01.11.2015
Saudi Chemical Society
Elsevier
Subjects
6-Amino uracil
Aldehydes
Anti-infective agents
Functionalized SBA-15
Malononitrile
Multicomponent reaction
Solvent free
Solvents
الأدوية
Malononitrile
Multicomponent reaction
6-Amino uracil
Aldehydes
Solvent free
Functionalized SBA-15
Online AccessGet full text

Cover

More Information
Summary:A simple and clean one-pot method for the preparation of 7-amino-2,4-dioxo-5-aryl-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile derivatives using 6-amino uracil, various aromatic aldehydes and malononitrile in the presence of sulfonic acid functionalized SBA-15 (SBA-Pr-SO3H) is described. Some of synthesized pyrido[2,3-d]pyrimidines showed antimicrobial activities against some fungi and gram positive and negative bacteria.
ISSN:1319-6103
DOI:10.1016/j.jscs.2014.06.007