Binding studies of an arabinogalactan-protein from Echinacea purpurea to leucocytes

Flow cytometric investigations show binding of an isolated arabinogalactan-protein (AGP) from pressed juice of the aerial parts of Echinacea purpurea to the cell surface of human leucocytes. AGP demonstrates binding to lymphocytes, monocytes and granulocytes of different donors ( n=8). Competition a...

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Published inPhytomedicine (Stuttgart) Vol. 13; no. 6; pp. 425 - 427
Main Authors Thude, S., Classen, B., Blaschek, W., Barz, D., Thude, H.
Format Journal Article
LanguageEnglish
Published Germany Elsevier GmbH 01.06.2006
Urban & Fischer Verlag
Subjects
Arabinogalactan-protein
Binding proteins
Echinacea
Echinacea purpurea
Flow Cytometry
Humans
Influence
Leukocytes
Leukocytes - metabolism
Mucoproteins - metabolism
Phytotherapy
Plant Components, Aerial
Plant Proteins - metabolism
Properties
Protein Binding
United States
Germany
Echinacea purpurea
Flow cytometry
Arabinogalactan-protein
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Summary:Flow cytometric investigations show binding of an isolated arabinogalactan-protein (AGP) from pressed juice of the aerial parts of Echinacea purpurea to the cell surface of human leucocytes. AGP demonstrates binding to lymphocytes, monocytes and granulocytes of different donors ( n=8). Competition assays with two antibodies, directed against CD4 and CD8, revealed no interaction of AGP with these receptors, leading to the conclusion that binding of AGP to leucocytes is mediated via other structures.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0944-7113
1618-095X
DOI:10.1016/j.phymed.2005.01.017