Nonneoplastic Lesions That Simulate Primary Tumors of Bone

Context.—The skeletal system may be affected by a variety of nonneoplastic lesions, which may potentially be confused with primary bone tumors on clinical, radiologic, and pathologic grounds. These conditions include fractures, infections, and reactive and degenerative processes, as well as an array...

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Bibliographic Details
Published inArchives of pathology & laboratory medicine (1976) Vol. 136; no. 7; pp. 772 - 788
Main Authors Remotti, Fabrizio, Feldman, Frieda
Format Journal Article
LanguageEnglish
Published United States College of American Pathologists 01.07.2012
Subjects
Biopsy
Bone and Bones - diagnostic imaging
Bone and Bones - pathology
Bone Diseases - diagnostic imaging
Bone Diseases - pathology
Bone Neoplasms - diagnostic imaging
Bone Neoplasms - pathology
Bones
Calcification
Cysts
Diagnosis
Diagnosis, Differential
Dysplasia
Ewings sarcoma
Fractures
Health aspects
Humans
Radiography
Tumors
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Summary:Context.—The skeletal system may be affected by a variety of nonneoplastic lesions, which may potentially be confused with primary bone tumors on clinical, radiologic, and pathologic grounds. These conditions include fractures, infections, and reactive and degenerative processes, as well as an array of quasineoplastic entities, such as intramedullary cystic lesions like unicameral and aneurysmal bone cysts; fibro-osseous lesions, such as fibrous dysplasia; and exophytic entities, like osteochondromas. Objective.—To review clinical, radiographic, and histologic features of nonneoplastic lesions of bone, discussing the difficulties in diagnosis and the differential diagnosis with primary neoplasms of bone. Data Sources.—The sources include the more relevant medical literature on the different subjects and case-derived material. Conclusions.—Because many nonneoplastic bone lesions may require biopsy or resection, the general surgical pathologist must be familiar with these lesions and be aware that review of hematoxylin-eosin slides is only one of the many steps in the diagnostic process, which also includes review of imaging studies and all available clinical information. Morphologic analysis disconnected from the clinical and radiographic context may lead to misinterpretation.
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ISSN:0003-9985
1543-2165
1543-2165
DOI:10.5858/arpa.2011-0557-RA