Olfactory Dysfunction in Patients With Coronavirus Disease 2019: A Review

The coronavirus disease 2019 (COVID-19) pandemic is wreaking havoc on public-health and economic systems worldwide. Among the several neurological symptoms of patients with COVID-19 reported in clinical practice, olfactory dysfunction (OD) is the most common. OD occurs as the earliest or the only cl...

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Published inFrontiers in neurology Vol. 12; p. 783249
Main Authors Wei, Guoli, Gu, Jialin, Gu, Zhancheng, Du, Cheng, Huang, Xiaofei, Xing, Haiyan, Li, Lingchang, Zhang, Aiping, Hu, Xingxing, Huo, Jiege
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 18.01.2022
Subjects
clinical characteristics
COVID-19
mechanism
Neurology
olfactory dysfunction
treatment
COVID-19
treatment
mechanism
olfactory dysfunction
clinical characteristics
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Summary:The coronavirus disease 2019 (COVID-19) pandemic is wreaking havoc on public-health and economic systems worldwide. Among the several neurological symptoms of patients with COVID-19 reported in clinical practice, olfactory dysfunction (OD) is the most common. OD occurs as the earliest or the only clinical manifestation in some patients. Increasing research attention has focused on OD, which is listed as one of the main diagnostic symptoms of severe acute respiratory syndrome-coronavirus-2 infection. Multiple clinical and basic-science studies on COVID-19-induced OD are underway to clarify the underlying mechanism of action. In this review, we summarize the clinical characteristics, mechanisms, evaluation methods, prognosis, and treatment options of COVID-19-induced OD. In this way, we hope to improve the understanding of COVID-19-induced OD to aid early identification and precise intervention.
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Reviewed by: Maria Paola Cecchini, University of Verona, Italy; Jorge Matias-Guiu, Complutense University of Madrid, Spain
This article was submitted to Neuromuscular Disorders and Peripheral Neuropathies, a section of the journal Frontiers in Neurology
Edited by: Ghazala Hayat, Saint Louis University, United States
These authors have contributed equally to this work
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2021.783249